7-Hydroxyflavanone | CAS:6515-36-2 | Manufacturer ChemFaces

7-Hydroxyflavanone

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Description:

7-Hydroxyflavanone shows antimicrobial activity against Streptococcus pneumoniae clinical isolates, it could be useful for the development of a novel respiratory infections treatment.

Targets:

Antifection

In vitro:

Phytother Res. 2011 Apr;25(4):615-8.

20S proteasome inhibitory activity of flavonoids isolated from Spatholobus suberectus.[Pubmed: 21104764 ]

The promising biological role of the ubiquitin proteasome pathway (UPP) in cancer therapy has recently emerged.
METHODS AND RESULTS:
Inhibition of proteasome has been proposed as a new therapeutic target for treatment of cancer. Bioassay-guided fractionation of a MeOH extract of the stems of Spatholobus suberectus resulted in seven compounds, liquiritigenin (1), isoliquiritigenin (2), genistein (3), daidzein (4), medicarpin (5), 7-Hydroxyflavanone (6) and formononetin (7), which were evaluated for the first time for their inhibitory effect on 20S proteasome. Among the isolated compounds, 2, 3 and 6 exhibited inhibitory activities on human 20S proteasome with IC(50) values of 4.88 ± 1.5, 9.26 ± 1.2 and 5.21 ± 1.5 μm, respectively.

In vivo:

J Ethnopharmacol. 2012 Mar 27;140(2):287-92.

Potentiality of standardized extract and isolated flavonoids from Zuccagnia punctata for the treatment of respiratory infections by Streptococcus pneumoniae: in vitro and in vivo studies.[Pubmed: 22285202 ]

Zuccagnia punctata Cav. (Fabaceae) is a monotypic species distributed in western Argentina and is traditionally used for the treatment of bacterial and fungal infections.
METHODS AND RESULTS:
The aim of this study was to demonstrated the antibacterial activity of the Zuccagnia punctata standardized extract and the structurally related non-methoxylated flavonoids with similar pattern of substitution and differences in ring C present in this plant species: 7-Hydroxyflavanone (HF), 2',4'-dihydroxychalcone (DHC) and 3,7-dihydroxyflavone (DHF), against Streptococcus pneumoniae clinical isolates using in vitro and in vivo models.All samples showed antimicrobial activity in vitro with MIC values between 50 and 500μg/ml. Zuccagnia punctata extract (1mg/mice) and HF (1mg/mice) significantly reduced the number of viable Streptococcus pneumoniae in lung (p<0.01) while lower quantities has not effect. Therefore, the present study has shown that intake once or twice a day of 1mg of Zuccagnia punctata extract or HF for seven days did not result in toxicity.
CONCLUSIONS:
Our results showed that Zuccagnia punctata extract as well as one of its isolated flavonoids, 7-Hydroxyflavanone, could be useful for the development of a novel respiratory infections treatment.

7-Hydroxyflavanone Description

Source:	The stems of Spatholobus suberectus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	7-Hydroxyflavanone
Price:	$50 / 20mg
CAS No.:	6515-36-2
Catalog No.:	CFN94487
Molecular Formula:	C₁₅H₁₂O₃
Molecular Weight:	240.26 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The stems of Spatholobus suberectus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Flavonoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1622 mL	20.8108 mL	41.6216 mL	83.2432 mL	104.0539 mL
5 mM	0.8324 mL	4.1622 mL	8.3243 mL	16.6486 mL	20.8108 mL
10 mM	0.4162 mL	2.0811 mL	4.1622 mL	8.3243 mL	10.4054 mL
50 mM	0.0832 mL	0.4162 mL	0.8324 mL	1.6649 mL	2.0811 mL
100 mM	0.0416 mL	0.2081 mL	0.4162 mL	0.8324 mL	1.0405 mL

CFN98740	Pinocembrin	480-39-7	256.3	C₁₅H₁₂O₄
CFN99096	Pinocembrin 7-acetate	109592-60-1	298.3	C₁₇H₁₄O₅
CFN99211	Pinocembrin diacetate	111441-88-4	340.3	C₁₉H₁₆O₆
CFN98739	Pinostrobin	480-37-5	270.3	C₁₆H₁₄O₄
CFN98489	Alpinetin	36052-37-6	270.3	C₁₆H₁₄O₄
CFN92662	5,7-Dimethoxyflavanone	1036-72-2	284.3	C₁₇H₁₆O₄
CFN90899	(2R)-5,7-Dimethoxyflavanone	1277188-85-8	284.31	C₁₇H₁₆O₄
CFN93796	Dihydrobaicalein	35683-17-1	272.3	C₁₅H₁₂O₅
CFN92591	Dihydrooroxylin A	18956-18-8	286.3	C₁₆H₁₄O₅
CFN92422	Onysilin	73695-94-0	300.3	C₁₇H₁₆O₅