7-O-Prenylscopoletin | CAS:13544-37-1 | Manufacturer ChemFaces

7-O-Prenylscopoletin

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Description:

7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.

Targets:

CDK | PLK

In vitro:

Planta Medica, 2012 , 78 (11) :1201-1201.

Mechanistic study of O-methylcedrelopsin and dehydrogeijerin[Reference: WebLink]

Plants that can survive in the harsh environment of South Texas have the potential to produce molecules with activity against diverse biological targets. The Mountain torchwood, Amyris madrensis, was evaluated because the crude lipophilic extract had potent activity against prostate cancer cells. Multiple cytotoxic compounds were isolated using bioassay guided fractionation including 14 previously identified coumarins. Two coumarins, O-methylcedrelopsin and dehydrogeijerin, were evaluated for antiproliferative activities against cancer cell lines. O-methylcedrelopsin has an IC50 of 7.8 and 27.8μM in HeLa and PC-3 cells respectively. Dehydrogeijerin also showed activity in the low micromolar range with an IC50 of 16.0μM in HeLa cells and 43.0μM in PC-3 cells. Both O-methylcedrelopsin and dehydrogeijerin caused a dose dependent accumulation of cells in G2/M as determined by flow cytometry. They have no effects on interphase microtubule structures or on the assembly of purified tubulin, suggesting a mechanism different from microtubule binding compounds. The compounds do however initiate the formation of abnormal mitotic spindles which closely resemble those formed following treatment of cells with mitotic kinase inhibitors. The hypothesis that O-methylcedrelopsin and dehydrogeijerin target mitotic kinases, specifically polo like kinase 1 (PLK1) or cyclin dependent kinase 1 (CDK1) is being tested. Two structurally similar coumarins, 7-O-Prenylscopoletin and cedrelopsin, were also identified but they have 10-fold lower antiproliferative potency. These structures will be informative in defining the moieties optimal for inhibiting mitotic progression.

7-O-Prenylscopoletin Description

Source:	The herbs of Ptaeroxylon obliquum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	7-O-Prenylscopoletin
Price:
CAS No.:	13544-37-1
Catalog No.:	CFN92639
Molecular Formula:	C₁₅H₁₆O₄
Molecular Weight:	260.3 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Cryst.
Source:	The herbs of Ptaeroxylon obliquum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Coumarins Compound Library PLK Inhibitor Library CDK Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8417 mL	19.2086 mL	38.4172 mL	76.8344 mL	96.043 mL
5 mM	0.7683 mL	3.8417 mL	7.6834 mL	15.3669 mL	19.2086 mL
10 mM	0.3842 mL	1.9209 mL	3.8417 mL	7.6834 mL	9.6043 mL
50 mM	0.0768 mL	0.3842 mL	0.7683 mL	1.5367 mL	1.9209 mL
100 mM	0.0384 mL	0.1921 mL	0.3842 mL	0.7683 mL	0.9604 mL

CFN99115	6,7-Dihydroxycoumarin	305-01-1	178.14	C₉H₆O₄
CFN93058	4-Methylesculetin	529-84-0	192.17	C₁₀H₈O₄
CFN99114	Esculin	531-75-9	340.28	C₁₅H₁₆O₉
CFN97684	Isoscopoletin	776-86-3	192.17	C₁₀H₈O₄
CFN90699	Magnolioside	20186-29-2	354.3	C₁₆H₁₈O₉
CFN97494	Scopoletin	92-61-5	192.2	C₁₀H₈O₄
CFN98951	Scopoletin acetate	56795-51-8	234.2	C₁₂H₁₀O₅
CFN92639	7-O-Prenylscopoletin	13544-37-1	260.3	C₁₅H₁₆O₄
CFN98348	7-Geranyloxy-6-methoxycoumarin	28587-43-1	328.4	C₂₀H₂₄O₄
CFN95196	Cichoriin	531-58-8	340.3	C₁₅H₁₆O₉