9-Methoxycanthin-6-one | CAS:74991-91-6

9-Methoxycanthin-6-one

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Description:

9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL.

In vitro:

Methods Mol Biol. 2009;547:359-69.

The Production of 9-methoxycanthin-6-one from Callus Cultures of (Eurycoma longifolia Jack) Tongkat Ali.[Pubmed: 19521859]

Plant cell culture technology is potentially useful in producing high-valued secondary metabolites. Eurycoma longifolia root extracts are consumed as a health tonic but more popularly used as an aphrodisiac. Studies on the aphrodisiac properties and the possible compounds involved have been widely studied.
METHODS AND RESULTS:
There are many potentially useful compounds reported from the root extracts of E. longifolia. However, studies on the in vitro production of useful compounds from this plant have not been reported. This chapter will describe methods of callus induction and extraction of 9-Methoxycanthin-6-one from E. longifolia Jack explants with emphasis on the tap and fibrous roots. This compound, known to have anti-tumour activity, is present in intact plant parts and in callus tissues of different explants.

Planta Med. 2002 Apr;68(4):355-8.

HPLC analysis of plasma 9-methoxycanthin-6-one from Eurycoma longifolia and its application in a bioavailability/pharmacokinetic study.[Pubmed: 11988862]

METHODS AND RESULTS:
A new and simple HPLC method using fluorescence detection was developed to determine 9-Methoxycanthin-6-one, an active compound of Eurycoma longifolia Jack in rat and human plasma. The method entailed direct injection of plasma sample after deproteinization using acetonitrile. The mobile phase comprised acetonitrile and distilled water (55 : 45, v/v). Analysis was run at a flow rate of 1.0 ml/min with the detector operating at an excitation wavelength of 371 nm and emission wavelength of 504 nm. The method was specific and sensitive with a detection limit of 0.6 ng/ml and a quantification limit of approximately 1.6 ng/ml.
CONCLUSIONS:
The method was applied in a pilot pharmacokinetic/bioavailability study of the compound in rats. Less than 1 % of the compound was found to be absorbed orally.

9-Methoxycanthin-6-one Description

Source:	The herbs of Eurycoma longifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	9-Methoxycanthin-6-one
Price:
CAS No.:	74991-91-6
Catalog No.:	CFN92011
Molecular Formula:	C₁₅H₁₀N₂O₂
Molecular Weight:	250.3 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The herbs of Eurycoma longifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Toxicity Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.9952 mL	19.976 mL	39.9521 mL	79.9041 mL	99.8801 mL
5 mM	0.799 mL	3.9952 mL	7.9904 mL	15.9808 mL	19.976 mL
10 mM	0.3995 mL	1.9976 mL	3.9952 mL	7.9904 mL	9.988 mL
50 mM	0.0799 mL	0.3995 mL	0.799 mL	1.5981 mL	1.9976 mL
100 mM	0.04 mL	0.1998 mL	0.3995 mL	0.799 mL	0.9988 mL

CFN98730	Canthin-6-one	479-43-6	220.2	C₁₄H₈N₂O
CFN92010	Canthin-6-one N-oxide	60755-87-5	236.2	C₁₄H₈N₂O₂
CFN97287	1-Hydroxycanthin-6-one	80787-59-3	236.2	C₁₄H₈N₂O₂
CFN92126	9-Hydroxycanthin-6-one	138544-91-9	236.2	C₁₄H₈N₂O₂
CFN94012	10-Hydroxycanthin-6-one	86293-41-6	236.23	C₁₄H₈N₂O₂
CFN92011	9-Methoxycanthin-6-one	74991-91-6	250.3	C₁₅H₁₀N₂O₂
CFN92012	9-Methoxycanthin-6-one-N-oxide	137739-74-3	266.3	C₁₅H₁₀N₂O₃
CFN92124	1-Hydroxy-9-medroxycanthin-6-one	622408-85-9	266.3	C₁₅H₁₀N₂O₃
CFN92125	11-Hydroxycanthin-6-one	75969-83-4	236.2	C₁₄H₈N₂O₂
CFN92127	9,10-Dimethoxycanthin-6-one	155861-51-1	280.3	C₁₆H₁₂N₂O₃