Acetagastrodin | CAS:64291-41-4 | Manufacturer ChemFaces

Acetagastrodin

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Description:

Acetagastrodin has antispasmodic effect on vascular smooth muscle. Acetagastrodin treatment may be an effective treatment to protect retinal neurons against such functional impairment during the early stages of diabetes.

In vivo:

Acta Diabetol. 2017 Jan;54(1):73-79.

Acetagastrodin effects on retinal oscillatory potentials in patients during the early stages of diabetes.[Pubmed: 27650536 ]

To investigate the protective effect of Acetagastrodin on visual electrophysiology in patients with early-stage diabetes.
METHODS AND RESULTS:
A prospective, randomized, controlled, double-blind trial was conducted. Subjects who were randomly assigned to either the treatment group or the control group were orally administered Acetagastrodin or placebo, respectively, for 6 months. The quantity, mean amplitude and mean latency of oscillatory potentials (OPs) wavelets at baseline and 6 months were measured on electroretinogram (ERG), in all subjects. A total of 92 right eyes in 92 patients with type 2 diabetes, who were diagnosed for the first time, were enrolled. Each group consisted of 46 cases (46 eyes). There was no significant difference in baseline characteristic between treatment and control groups at baseline, but quantity in treatment group was more than that in control group at 6 months (P = 0.001). The mean amplitude of OPs was reduced in the control group 6 months later compared with treatment group (P = 0.001). As to mean latency of OPs, statistical difference was also detectable between the treatment group and control group 6 months later (P < 0.001). No statistical differences were found in hemoglobin between both groups at 6 months (P > 0.05).
CONCLUSIONS:
Electrophysiological changes would go on worsening even hemoglobin was under control during the initial stage of diabetes. Acetagastrodin treatment may be an effective treatment to protect retinal neurons against such functional impairment during the early stages of diabetes.

Acetagastrodin Description

Source:	The herbs of Gastrodia elata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Acetagastrodin
Price:
CAS No.:	64291-41-4
Catalog No.:	CFN80033
Molecular Formula:	C₂₁H₂₆O₁₁
Molecular Weight:	454.43 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Gastrodia elata
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2006 mL	11.0028 mL	22.0056 mL	44.0112 mL	55.014 mL
5 mM	0.4401 mL	2.2006 mL	4.4011 mL	8.8022 mL	11.0028 mL
10 mM	0.2201 mL	1.1003 mL	2.2006 mL	4.4011 mL	5.5014 mL
50 mM	0.044 mL	0.2201 mL	0.4401 mL	0.8802 mL	1.1003 mL
100 mM	0.022 mL	0.11 mL	0.2201 mL	0.4401 mL	0.5501 mL

CFN90927	Hydroxytyrosol acetate	69039-02-7	196.2	C₁₀H₁₂O₄
CFN96586	p-Hydroxyphenethyl anisate	87932-34-1	272.30	C₁₆H₁₆O₄
CFN89272	p-Hydroxyphenethyl vanillate	1539303-03-1	288.29	C₁₆H₁₆O₅
CFN97575	4'-Hydroxyacetophenone	99-93-4	136.2	C₈H₈O₂
CFN97063	4-Hydroxybenzamide	619-57-8	137.1	C₇H₇NO₂
CFN97577	4-Hydroxybenzoic acid	99-96-7	138.1	C₇H₆O₃
CFN97571	Methyl 4-hydroxybenzoate	99-76-3	152.2	C₈H₈O₃
CFN99320	Ethylparaben	120-47-8	166.2	C₉H₁₀O₃
CFN92421	p-Ethoxybenzoic acid	619-86-3	166.2	C₉H₁₀O₃
CFN97923	4-Hydroxyphenylacetic acid	156-38-7	152.2	C₈H₈O₃