Agatharesinol acetonide | CAS:800389-33-7

Agatharesinol acetonide

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Description:

Agatharesinol acetonide shows anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM).

Targets:

Antifection

In vitro:

Chem Biodivers. 2005 Apr;2(4):497-505.

Norlignans from Sequoia sempervirens.[Pubmed: 17191998]

METHODS AND RESULTS:
Six new norlignans, named sequosempervirins B-G (1-6), together with three known norlignans, agatharesinol (7), Agatharesinol acetonide (8), and sugiresinol (9), were isolated from the branches and leaves of Sequoia sempervirens. Their structures were determined mainly by high-resolution mass spectroscopy (HR-MS), and various 1D- and 2D-NMR methods, as well as, in the case of 1, by means of X-ray diffraction.
CONCLUSIONS:
Compound 8 showed anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM). The acetone extract of S. sempervirens was found to be antifungal towards Candida glabrata (IC50 = 15.98 microg/ml), and both the acetone and MeOH extracts inhibited the proteolytic activity of cathepsin B (IC50 = 4.58 and 5.49 microg/ml, resp.).

Agatharesinol acetonide Description

Source:	The heartwoods of Sequoia sempervirens
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Agatharesinol acetonide
Price:
CAS No.:	800389-33-7
Catalog No.:	CFN97675
Molecular Formula:	C₂₀H₂₂O₄
Molecular Weight:	326.39 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The heartwoods of Sequoia sempervirens
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Lignans Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0638 mL	15.3191 mL	30.6382 mL	61.2764 mL	76.5955 mL
5 mM	0.6128 mL	3.0638 mL	6.1276 mL	12.2553 mL	15.3191 mL
10 mM	0.3064 mL	1.5319 mL	3.0638 mL	6.1276 mL	7.6595 mL
50 mM	0.0613 mL	0.3064 mL	0.6128 mL	1.2255 mL	1.5319 mL
100 mM	0.0306 mL	0.1532 mL	0.3064 mL	0.6128 mL	0.766 mL

CFN99834	trans-Hinokiresinol	17676-24-3	252.3	C₁₇H₁₆O₂
CFN97696	Agatharesinol	7288-11-1	286.33	C₁₇H₁₈O₄
CFN97675	Agatharesinol acetonide	800389-33-7	326.39	C₂₀H₂₂O₄
CFN97801	Sequirin C	18194-29-1	302.33	C₁₇H₁₈O₅
CFN97905	Sequosempervirin B	864719-17-5	316.4	C₁₈H₂₀O₅
CFN97603	Sequosempervirin D	864719-19-7	356.42	C₂₁H₂₄O₅
CFN97909	Metasequirin D	1264694-96-3	346.4	C₁₉H₂₂O₆