| Description: |
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks. Alismol acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release. Alismol has inhibitory effect to MMP3 expression and nitric oxide produced in microglial cells. It holds great promise for use in chemopreventive and chemotherapeutic strategies.
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| Targets: |
Calcium Channel | Potassium Channel | PI3K | Akt | ERK | JNK | Caspase | MMP(e.g.TIMP) |
| In vitro: |
| Jpn J Pharmacol. 1988 Apr;46(4):331-5. | | Effect of alismol on adrenergic mechanism in isolated rabbit ear artery.[Pubmed: 3404764 ] | Effects of Alismol, a sesquiterpenoid isolated from the rhyzome of Alisma orientale, on adrenergic mechanisms were examined in the isolated rabbit ear artery.
METHODS AND RESULTS:
Alismol (10(-6) to 10(-4) M) inhibited the contraction of isolated rabbit ear artery by electrical stimulation of the perivascular nerves. The inhibition was concentration-dependent; at a concentration of 10(-4) M, the inhibition was 90% (n = 8). Treatment with 10(-4) M Alismol inhibited the increase in 3H-noradrenaline (3H-NAd) release induced by electrical stimulation by 63 +/- 6%. Alismol at 10(-4) M did not affect the neuronal uptake of 3H-NAd in the artery. Alismol at 10(-4) M slightly inhibited contractions induced by exogenously administered NAd.
CONCLUSIONS:
These results demonstrate that Alismol inhibits the adrenergic neuro-effector mechanisms in rabbit ear artery, and they suggest that Alismol acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release. | | Life Sci. 1987 Oct 12;41(15):1845-52. | | Effects of alismol isolated from Alismatis Rhizoma on calcium-induced contraction in the rabbit thoracic aorta.[Pubmed: 3657386] |
METHODS AND RESULTS:
We examined the inhibitory effects of Alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, on vascular contractions induced by high concentrations of K+ and Ca2+, and on 45Ca2+ retention in normal and in high K+-containing medium. Alismol affected neither the resting tension nor the 45Ca2+ retention in normal medium, but it inhibited sustained contraction and increased 45Ca2+ retention induced by high K+ concentrations. Alismol did not affect norepinephrine-induced contractions in normal medium, nor phasic contractions in Ca2+-free medium.
CONCLUSIONS:
These results suggested that Alismol inhibited mainly Ca2+ influx through a voltage-dependent Ca2+ channel. | | Phytother. Res., 1989, 3(2):72-4. | | Effect of alismol isolated from Alismatis Rhizoma on working heart perfusion in rat.[Reference: WebLink] |
METHODS AND RESULTS:
The effect of Alismol (Oshima et al., 1983), a sesquiterpenoid isolated from Alismatis Rhizoma which is used as a Chinese crude drug, was studied on rat isolated heart using the working heart perfusion technique. Alismol decreased cardiac output, heart rate and left ventricular pressure, but it increased coronary flow.
CONCLUSIONS:
The drug has been used for the prevention of anginal attacks and our results provide a pharmacological basis for one of the traditional medicinal effects of Alismatis Rhizoma. |
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| In vivo: |
| Phytother. Res., 1989, 3(2):57-60. | | The effect of alismol isolated from Alismatis Rhizoma on experimental hypertensive models in rats.[Reference: WebLink] |
METHODS AND RESULTS:
The antihypertensive action of Alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, the rhizome of Alisma orientale Juzepczuk (Alismataceae), was examined in various experimental hypertensive models in rats and the effect of Alismol on the activation of plasma renin, angiotensin-converting enzyme (ACE) and the level of aldosterone were examined in 2-kidney, 1-clip hypertensive model.
CONCLUSIONS:
Alismol caused a sustained, though weak, antihypertensive action in all the experimental models, but did not significantly affect the plasma renin activity, ACE activity and the level of aldosterone.
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