Andropanolide | CAS:869807-57-8 | Manufacturer ChemFaces

Andropanolide

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Description:

Andropanolide is a natural product from Andrographis paniculata (Burm. f.) Nees.

In vitro:

International Journal of Pharmacy & Pharmaceutical Sciences, 2014, 6(1):46–52.

MICROBIAL METABOLISM OF AN ANTI-HIV AND ANTI-MALARIAL NATURAL PRODUCT ANDROGRAPHOLIDE[Reference: WebLink]

In the present study, we first time studied the microbial metabolism of andrographolide (1) with Cunninghamella elegans (TSY 0865) and Cephalosporium aphidicola (IMI-68689).
METHODS AND RESULTS:
Microbial cultures of the C. elegans and C. aphidicola were grown on Potato dextrose agar (PDA) at 25°C and stored at 4°C. Medium for C. aphidicola was prepared by mixing Glucose (50.0 g), KH2PO4 (1.0 g), MgSO4.7H2O (2.0 g), Glycin (2.0 g), KCl (1.0 g) and Gibberella trace element solution (2.0 mL) into distilled water (1 L) and maintained pH at 5.6. While C. elegans medium was prepared by adding Glucose (10.0 g), peptone (5.0 g), KH2PO4 .Two compounds were obtained as transformed products. Based on physical and spectroscopic data, these have been identified as Andropanolide (2) and 14-deoxy-11,12-didehydro andrographolide (3). Both compounds were previously obtained by the phytochemical investigation of A. paniculata and biotransformed product as well. (5.0 g), yeast extract (5.0 g), NaCl (5.0 g) and glycerol (10 mL) into distilled water (1 L) and maintained pH at 5.6.
CONCLUSIONS:
It could be concluded that C. elegans and C. aphidicola were able to produce oxidative derivatives of 1 in a regio- and stereoselective manner. Present investigation has been conducted for the first time with C. elegans and C. aphidicola. Incubation of 1 for 9 days with fungal strains yielded isomerized and oxidative products 2 and 3. Structures of all metabolites were elucidated by using spectroscopic techniques.

Andropanolide Description

Source:	The herbs of Andrographis paniculata (Burm. f.) Nees
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Andropanolide
Price:
CAS No.:	869807-57-8
Catalog No.:	CFN97600
Molecular Formula:	C₂₀H₃₀O₅
Molecular Weight:	350.45 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Andrographis paniculata (Burm. f.) Nees
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8535 mL	14.2674 mL	28.5347 mL	57.0695 mL	71.3369 mL
5 mM	0.5707 mL	2.8535 mL	5.7069 mL	11.4139 mL	14.2674 mL
10 mM	0.2853 mL	1.4267 mL	2.8535 mL	5.7069 mL	7.1337 mL
50 mM	0.0571 mL	0.2853 mL	0.5707 mL	1.1414 mL	1.4267 mL
100 mM	0.0285 mL	0.1427 mL	0.2853 mL	0.5707 mL	0.7134 mL

CFN99770	Dehydroandrographolide	134418-28-3	332.43	C₂₀H₂₈O₄
CFN92802	14-Deoxyandrographolide	4176-97-0	334.45	C₂₀H₃₀O₄
CFN90518	Deoxyandrographolide	79233-15-1	334.45	C₂₀H₃₀O₄
CFN97601	14-Deoxy-17-hydroxyandrographolide	869384-82-7	352.47	C₂₀H₃₂O₅
CFN97815	14-Deoxy-11-hydroxyandrographolide	160242-09-1	350.45	C₂₀H₃₀O₅
CFN97785	14-Deoxy-12-hydroxyandrographolide	219721-33-2	350.45	C₂₀H₃₀O₅
CFN96446	Vitexolide D	1788090-69-6	318.45	C₂₀H₃₀O₃
CFN91445	Isoandrographolide	4176-96-9	350.5	C₂₀H₃₀O₅
CFN98923	Andrographolide	5508-58-7	350.5	C₂₀H₃₀O₅
CFN98666	14-Deoxy-11,12-didehydroandrographolide	42895-58-9	332.4	C₂₀H₂₈O₄