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Atroscine
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Product Name Atroscine
Price:
CAS No.: 138-12-5
Catalog No.: CFN00227
Molecular Formula: C17H21NO4
Molecular Weight: 303.36 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Atropa belladonna L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Atroscine has adrenolytic activity by its ability to antagonize the lethal effect of epinephrine in rats.
Targets: Adrenergic Receptor
In vivo:
Journal of Pharmaceutical Sciences,1966,55(3):280-284.
Adrenolytic activity of atropine, (+)-hyoscyamine, atroscine, homatropine, and related compounds[Reference: WebLink]

METHODS AND RESULTS:
The adrenolytic activity of atropine, ( + ) and (−) hyoscyamine, (−)-hyoscine, Atroscine, and related compounds was determined by their ability to antagonize the lethal effect of epinephrine in rats. (+)-Hyoscyamine was found to be more active than atropine, and atropine was slightly more active than Atroscine (racemic hyos-cine). The levo-isomers, ( − )-hyoscyamine and (−)-hyoscine, were inactive. These results indicate that (+)-hyoscyamine and (+)-hyoscine are responsible for the effect of atropine and Atroscine, respectively.
CONCLUSIONS:
Hornatropine and benztropine, but not tropine itself, were active. Benztropine was approximately one-fiftieth as active as phentolamine. A pair of esters of tropine had weak adrenoiytic activity, but their pseudotropine isomers were inactive. Atropine aminoxide (genatropin) and atropine methyl nitrate had no adrenolytic activity.
Atroscine Description
Source: The herbs of Atropa belladonna L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2964 mL 16.4821 mL 32.9641 mL 65.9283 mL 82.4103 mL
5 mM 0.6593 mL 3.2964 mL 6.5928 mL 13.1857 mL 16.4821 mL
10 mM 0.3296 mL 1.6482 mL 3.2964 mL 6.5928 mL 8.241 mL
50 mM 0.0659 mL 0.3296 mL 0.6593 mL 1.3186 mL 1.6482 mL
100 mM 0.033 mL 0.1648 mL 0.3296 mL 0.6593 mL 0.8241 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Eur J Pharmacol. 1983 May 20;90(1):75-83.
Structure-activity requirements for hypotension and alpha-adrenergic receptor blockade by analogues of atropine.[Pubmed: 6135619 ]
The hypotensive action of various antimuscarinic compounds structurally related to atropine was studied in conscious, unanesthetized rats.
METHODS AND RESULTS:
The alpha-adrenolytic activity of these agents was assessed both in vivo (blockade of norepinephrine-induced pressor response) and in vitro (displacement of [3H]WB-4101 binding). Benztropine, homatropine and hyoscyamine caused hypotension and produced alpha-adrenergic receptor blockade similar to atropine. Other analogues were either inactive (Atroscine, scopolamine, tropic acid and tropine) or evoked nonspecific changes in blood pressure and lacked alpha-adrenolytic activity (benactyzine, eucatropine, methylatropine, methylhomatropine and methylscopolamine).
CONCLUSIONS:
Based on these data, we propose the following structure-activity relationship for hypotension and alpha-adrenolytic activity: (a) the tropine moiety is inactive unless it is attached to another group by an ester linkage, (b) chemical modification of the tropine moiety, including quaternization, decreases potency, (c) the d-stereoisomer appears to be more potent than the corresponding 1-form.
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