Bakkenolide B | CAS:18455-98-6 | Manufacturer ChemFaces

Bakkenolide B

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Description:

Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.

Targets:

NOS | COX

In vitro:

J Ethnopharmacol. 2013 Jul 30;148(3):890-4.

Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves.[Pubmed: 23711828 ]

To elucidate the anti-allergic and anti-inflammatory effects of Petasites genus, we studied the effects of several compounds isolated from Petasites japonicas leaves.
METHODS AND RESULTS:
Bakkenolide B was isolated from Petasites japonicus leaves. Antigen-induced degranulation was measured in RBL-2H3 mast cells by measuring β-hexosamidase activity. Induction of inducible nitric oxide synthase and cyclooxygenase 2 was measured by Western blotting in peritoneal macrophages. Ovalbumin-induced asthma model was used for in vivo efficacy test of bakkanolide B. We found that Bakkenolide B, a major component of the leaves, concentration-dependently inhibited RBL-2H3 mast cell degranulation. Bakkenolide B also inhibited the gene inductions of inducible nitric oxide synthase and cyclooxygenase 2 in mouse peritoneal macrophages. Furthermore, in an ovalbumin-induced asthma model, Bakkenolide B strongly inhibited the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid.
CONCLUSIONS:
Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.

Bakkenolide B Description

Source:	The leaves of Peatasites japonicus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Bakkenolide B
Price:
CAS No.:	18455-98-6
Catalog No.:	CFN96902
Molecular Formula:	C₂₂H₃₀O₆
Molecular Weight:	390.47 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The leaves of Peatasites japonicus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Anti-allergy Compound Library Sesquiterpenoids Compound Library NOS Inhibitor Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.561 mL	12.8051 mL	25.6102 mL	51.2203 mL	64.0254 mL
5 mM	0.5122 mL	2.561 mL	5.122 mL	10.2441 mL	12.8051 mL
10 mM	0.2561 mL	1.2805 mL	2.561 mL	5.122 mL	6.4025 mL
50 mM	0.0512 mL	0.2561 mL	0.5122 mL	1.0244 mL	1.2805 mL
100 mM	0.0256 mL	0.1281 mL	0.2561 mL	0.5122 mL	0.6403 mL

CFN98579	Bakkenolide A	19906-72-0	234.34	C₁₅H₂₂O₂
CFN96942	Bakkenolide III	24909-95-3	266.33	C₁₅H₂₂O₄
CFN96812	1-Oxobakkenolide S	18456-02-5	264.32	C₁₅H₂₀O₄
CFN96902	Bakkenolide B	18455-98-6	390.47	C₂₂H₃₀O₆
CFN89054	Bakkenolide IIIa	915289-60-0	448.57	C₂₄H₃₂O₆S
CFN90795	Bakkenolide D	18456-03-6	408.5	C₂₁H₂₈O₆S
CFN96815	Bakkenolide Db	226711-23-5	424.50	C₂₁H₂₈O₇S
CFN97495	Glochicoccin D	927812-23-5	436.4	C₂₁H₂₄O₁₀
CFN99518	Muscone	541-91-3	238.42	C₁₆H₃₀O
CFN92687	Officinaruminane B	1246282-67-6	400.6	C₂₉H₃₆O