Bursehernin | CAS:40456-51-7 | Manufacturer ChemFaces

Bursehernin

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Bursehernin has potential for development as an anti-tumor agent with an anti-proliferation, and cell cycle arrest inducing.

In vitro:

J Mol Graph Model. 2017 Jun;74:215-224.

Structure-guided cancer blockade between bioactive bursehernin and proteins: Molecular docking and molecular dynamics study.[Pubmed: 28456097 ]

Bursehernin (5'-desmethoxyyatein) is a natural lignan, which has anti-tumor activity in vitro.
METHODS AND RESULTS:
In this study, the binding-inhibitory effects of Bursehernin were screening on selected 80 proteins associated with cancer pathway. The computational analysis suggested inhibitory effect due to Bursehernin towards proteins related to cancer proliferation, including FMS kinase receptor, heat shock protein 90-α (Hsp90-α), adenylate cyclase 10 (ADCY10), mitogen-activated protein kinase kinase (MEK1), and α-tubulin. Moreover, Bursehernin could interfere with cell cycle progression via binding to cyclin B proteins. Among all screened proteins, the compound showed an interesting binding affinity to the FMS kinase receptor. The binding mode studies by molecular dynamic technique showed that aromatic ring of Bursehernin compound was responsible for compound-protein interaction through pi-pi stacking with Tyr105 and Phe178 of the FMS kinase receptor.
CONCLUSIONS:
This study suggests that Bursehernin has potential for development as an anti-tumor agent with an anti-proliferation, and cell cycle arrest inducing, although further studies are needed.

Bursehernin Description

Source:	The herbs of Macaranga tanarius
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Bursehernin
Price:
CAS No.:	40456-51-7
Catalog No.:	CFN92058
Molecular Formula:	C₂₁H₂₂O₆
Molecular Weight:	370.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The herbs of Macaranga tanarius
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-proliferation Compound Library Lignans Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6998 mL	13.4989 mL	26.9978 mL	53.9957 mL	67.4946 mL
5 mM	0.54 mL	2.6998 mL	5.3996 mL	10.7991 mL	13.4989 mL
10 mM	0.27 mL	1.3499 mL	2.6998 mL	5.3996 mL	6.7495 mL
50 mM	0.054 mL	0.27 mL	0.54 mL	1.0799 mL	1.3499 mL
100 mM	0.027 mL	0.135 mL	0.27 mL	0.54 mL	0.6749 mL

CFN99991	Arctiin	20362-31-6	534.55	C₂₇H₃₄O₁₁
CFN90714	Arctigenin 4'-O-beta-gentiobioside	41682-24-0	696.69	C₃₃H₄₄O₁₆
CFN89301	Matairesinoside	23202-85-9	520.53	C₂₆H₃₂O₁₁
CFN90715	Matairesinol 4'-O-beta-gentiobioside	106647-14-7	682.25	C₃₂H₄₂O₁₆
CFN92253	(-)-Haplomyrfolin	85404-48-4	356.4	C₂₀H₂₀O₆
CFN92254	Kusunokinin	58311-20-9	370.4	C₂₁H₂₂O₆
CFN92058	Bursehernin	40456-51-7	370.4	C₂₁H₂₂O₆
CFN92255	(-)-Hinokinin	26543-89-5	354.4	C₂₀H₁₈O₆
CFN98635	Yatein	40456-50-6	400.4	C₂₂H₂₄O₇
CFN92816	Epinortrachelogenin	125072-69-7	374.4	C₂₀H₂₂O₇