Cannabichromevarinic acid | CAS:64898-02-8

Cannabichromevarinic acid

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Description:

Cannabichromevarinic acid has anticonvulsant properties

In vivo:

ACS Chem Neurosci . 2021 Jan 20;12(2):330-339.

Cannabichromene, Related Phytocannabinoids, and 5-Fluoro-cannabichromene Have Anticonvulsant Properties in a Mouse Model of Dravet Syndrome[Pubmed: 33395525]

Cannabis-based products are increasingly being used to treat refractory childhood epilepsies such as Dravet syndrome. Cannabis contains at least 140 terpenophenolic compounds known as phytocannabinoids. These include the known anticonvulsant compound cannabidiol (CBD) and several molecules showing emergent anticonvulsant properties in animal models. Cannabichromene (CBC) is a phytocannabinoid frequently detected in artisanal cannabis oils used in the community by childhood epilepsy patients. Here we examined the brain and plasma pharmacokinetic profiles of CBC, cannabichromenic acid (CBCA), cannabichromevarin (CBCV), and Cannabichromevarinic acid (CBCVA) following intraperitoneal administration in mice. The anticonvulsant potential of each was then tested against hyperthermia-induced seizures in the Scn1a+/- mouse model of Dravet syndrome. All phytocannabinoids within the CBC series were readily absorbed and showed substantial brain penetration (brain-plasma ratios ranging from 0.2 to 5.8). Anticonvulsant efficacy was evident with CBC, CBCA, and CBCVA, each significantly increasing the temperature threshold at which Scn1a+/- mice had a generalized tonic-clonic seizure. We synthesized a fluorinated derivative of CBC (5-fluoro-CBC), which showed improved brain penetration relative to the parent CBC molecule but not any greater anticonvulsant effect. Since CBC and derivatives are anticonvulsant in a model of intractable pediatric epilepsy, they may constitute part of the mechanism through which artisanal cannabis oils are anticonvulsant in patients.

Cannabichromevarinic acid Description

Source:	The herbs of Cannabis sativa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cannabichromevarinic acid
Price:
CAS No.:	64898-02-8
Catalog No.:	CFN91609
Molecular Formula:	C₂₀H₂₆O₄
Molecular Weight:	330.42 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Cannabis sativa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0265 mL	15.1323 mL	30.2645 mL	60.529 mL	75.6613 mL
5 mM	0.6053 mL	3.0265 mL	6.0529 mL	12.1058 mL	15.1323 mL
10 mM	0.3026 mL	1.5132 mL	3.0265 mL	6.0529 mL	7.5661 mL
50 mM	0.0605 mL	0.3026 mL	0.6053 mL	1.2106 mL	1.5132 mL
100 mM	0.0303 mL	0.1513 mL	0.3026 mL	0.6053 mL	0.7566 mL

CFN99828	Nervogenic acid	17622-86-5	274.4	C₁₇H₂₂O₃
CFN99652	4-Hydroxy-3-(3-methyl-2-butenoyl)-5-(3-methyl-2-butenyl)benzoic acid	155051-85-7	288.3	C₁₇H₂₀O₄
CFN99633	2,2-Dimethyl-8-prenylchromene 6-carboxylic acid	151731-50-9	272.3	C₁₇H₂₀O₃
CFN91610	Cannabigerovarinic acid	64924-07-8	332.43	C₂₀H₂₈O₄
CFN98287	Cannabigerol	25654-31-3	316.5	C₂₁H₃₂O₂
CFN98039	Cannabichromene	20675-51-8	314.5	C₂₁H₃₀O₂
CFN91609	Cannabichromevarinic acid	64898-02-8	330.42	C₂₀H₂₆O₄
CFN91611	Cannabichromenic acid	185505-15-1	358.47	C₂₂H₃₀O₄
CFN95162	Atractylochromene	203443-33-8	258.4	C₁₇H₂₂O₂
CFN91935	Denudaquinol	1189105-40-5	318.41	C₁₉H₂₆O₄