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Cedrin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cedrin
Price:
CAS No.: 75513-81-4
Catalog No.: CFN97872
Molecular Formula: C16H14O8
Molecular Weight: 334.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The herbs of Cedrus deodara
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis.
Targets: Bcl-2/Bax | Caspase | Beta Amyloid
In vivo:
Nat Prod Res. 2017 Jun 29:1-4.
Cedrin identified from Cedrus deodara (Roxb.) G. Don protects PC12 cells against neurotoxicity induced by Aβ1-42.[Pubmed: 28658984 ]
Alzheimer's disease is a severe neurodegenerative disease affecting elder worldwide and closely related to the neurotoxicity induced by amyloid β.
METHODS AND RESULTS:
To find efficient therapeutics, we have investigated the protective effects of Cedrin from Cedrus deodara (Roxb.) G. Don on PC12 cells against the neurotoxicity induced by amyloid β1-42. The results have shown the viability of PC12 cells injured by amyloid β1-42 can be improved by Cedrin. Cedrin can reduce reacrive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content. Meanwhile, the loss of mitochondrial membrane potential and mitochondrial permeability transition pore opening in PC12 cells, and elevated Caspase-3 activity, downregulated Bcl-2 and upregulated Bax are meliorated.
CONCLUSIONS:
These results demonstrate the protective effect of Cedrin is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. This investigation gives evidences for the application of Cedrin in practice and further investigation in vivo.
Cedrin Description
Source: The herbs of Cedrus deodara
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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PMID: 32004475

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doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

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Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9913 mL 14.9566 mL 29.9133 mL 59.8265 mL 74.7831 mL
5 mM 0.5983 mL 2.9913 mL 5.9827 mL 11.9653 mL 14.9566 mL
10 mM 0.2991 mL 1.4957 mL 2.9913 mL 5.9827 mL 7.4783 mL
50 mM 0.0598 mL 0.2991 mL 0.5983 mL 1.1965 mL 1.4957 mL
100 mM 0.0299 mL 0.1496 mL 0.2991 mL 0.5983 mL 0.7478 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Oxymatrine

Catalog No: CFN99805
CAS No: 16837-52-8
Price: $40/20mg
(+)-Lyoniresinol 9'-O-glucoside

Catalog No: CFN97964
CAS No: 87585-32-8
Price: $318/10mg
Alisol O

Catalog No: CFN92404
CAS No: 928148-51-0
Price: $ / mg
Shuterin

Catalog No: CFN91904
CAS No: 105377-77-3
Price: $ / mg
Phloretin

Catalog No: CFN97040
CAS No: 60-82-2
Price: $40/20mg
Linolenic acid

Catalog No: CFN70110
CAS No: 463-40-1
Price: $30/20mg
3'-Demethylnobiletin

Catalog No: CFN93130
CAS No: 112448-39-2
Price: $188/10mg
Maackiain

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Ergosterol peroxide

Catalog No: CFN98035
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Aloeemodin

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CAS No: 481-72-1
Price: $30/20mg
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