Science | Nature | Cell | View More
Natural Products
Chiisanoside
Chiisanoside
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Chiisanoside
Price:
CAS No.: 89354-01-8
Catalog No.: CFN90571
Molecular Formula: C48H74O19
Molecular Weight: 955.10 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: White powder
Source: The herbs of Acanthopanax brachypus Harms
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Virginia (USA)
  • Tohoku University (Japan)
  • Mendel University in Brno (Czech Republic)
  • Kitasato University (Japan)
  • Monash University (Australia)
  • Yale University (USA)
  • Uniwersytet Gdański (Poland)
  • University of Wollongong (Australia)
  • The Vancouver Prostate Centre (... (Canada)
  • University of Hull (United Kingdom)
  • University of Indonesia (Indonesia)
  • More...
Package
Featured Products
Calycosin

Catalog No: CFN99140
CAS No: 20575-57-9
Price: $80/20mg
Ginsenoside Rg5

Catalog No: CFN92643
CAS No: 186763-78-0
Price: $238/20mg
Neogambogic acid

Catalog No: CFN90175
CAS No: 93772-31-7
Price: $258/20mg
Cineole

Catalog No: CFN90545
CAS No: 470-82-6
Price: $30/20mg
Dauricine

Catalog No: CFN98129
CAS No: 524-17-4
Price: $98/20mg
N1,N10-Bis(p-coumaroyl)spermidine

Catalog No: CFN99248
CAS No: 114916-05-1
Price: $ /
Chicoric acid

Catalog No: CFN99725
CAS No: 6537-80-0
Price: $70/20mg
Crocin

Catalog No: CFN90227
CAS No: 42553-65-1
Price: $40/20mg
11-Oxomogroside III

Catalog No: CFN92192
CAS No: 952481-53-7
Price: $318/10mg
Ginsenoside Rk1

Catalog No: CFN92644
CAS No: 494753-69-4
Price: $188/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Chiisanoside has anti-oxidant, anti-inflammatory, anti-rotaviral activities, it can inhibit xanthine oxidase activity and increase superoxide dismutase (SOD), glutathione peroxidase and catalase, it also inhibits NO and PGE2 production. Chiisanoside has the potential to prevent obesity as a lipase inhibitor which suppresses fat absorption in vivo.
Targets: NO | PGE | TNF-α | NOS | COX | NF-kB | IL Receptor | p65 | ERK | JNK | ATPase | Potassium Channel | SOD | ROS
In vitro:
Biol Pharm Bull. 2005 Oct;28(10):1919-24.
Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide and cyclooxygenase-2 by chiisanoside via suppression of nuclear factor-kappaB activation in RAW 264.7 macrophage cells.[Pubmed: 16204946]

METHODS AND RESULTS:
In the present study, the effects of several triterpenes isolated from the leaves of Acanthopanax chiisanensis (Araliaceae), namely, Chiisanoside, isoChiisanoside, 22-hydroxyChiisanoside and chiisanogenin (the aglycone of Chiisanoside) were evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by the RAW 264.7 macrophage cell line. Of the triterpenes tested, Chiisanoside was found to most potently inhibit NO and PGE2 production. In addition, Chiisanoside significantly reduced the release of inflammatory cytokines like TNF-alpha and IL-1beta. Consistent with these observations, the protein and mRNA expression levels of iNOS and COX-2 enzyme were found to be inhibited by Chiisanoside in a concentration-dependent manner. Furthermore, Chiisanoside inhibited the nuclear factor-kappaB (NF-kappaB) activation induced by LPS and this was associated with a reduction in p65 protein in the nucleus and with the phosphorylations of ERK1/2 and JNK MAP kinases.
CONCLUSIONS:
Taken together, our data indicate that the anti-inflammatory properties of Chiisanoside might be the result from the inhibition of iNOS, COX-2, TNF-alpha and IL-1beta expression through the down-regulation of NF-kappaB binding activity.
Biol Pharm Bull. 2001 May;24(5):582-5.
Metabolism of chiisanoside from Acanthopanax divaricatus var. albeofructus by human intestinal bacteria and its relation to some biological activities.[Pubmed: 11379786]

METHODS AND RESULTS:
The metabolic pathway of Chiisanoside isolated from leaves of Acanthopanax divaricatus var. albeofructus (Araliaceae) by human intestinal bacteria and by the protein fraction of leaves of this plant were investigated, and the cytotoxic and anti-rotaviral activities of Chiisanoside and its metabolite, chiisanogenin, were assayed. Chiisanogenin was produced as a main metabolite, when Chiisanoside were incubated for 15 h with human intestinal bacteria. This metabolic pathway proceeded more potently with the protein fraction than with human intestinal bacteria.
CONCLUSIONS:
The in vitro cytotoxicity of chiisanogenin was superior to that of Chiisanoside. H+/K+ ATPase was more potently inhibited by chiisanogenin than by Chiisanoside. However, the anti-rotaviral activity of Chiisanoside was more potent than that of chiisanogenin.
In vivo:
Biosci Biotechnol Biochem. 2008 Apr;72(4):1126-9.
Chiisanoside is not absorbed but inhibits oil absorption in the small intestine of rodents.[Pubmed: 18391464]

METHODS AND RESULTS:
Chiisanoside is the main component of Acanthopanax sessiliflorus leaves. Simultaneous administration of Chiisanoside resulted in a decrease in the plasma TG level and increase of undigested TG in the intestinal lumen after oil gavage to mice.
CONCLUSIONS:
This suggests that Chiisanoside has the potential to prevent obesity as a lipase inhibitor which suppresses fat absorption in vivo.
Chiisanoside Description
Source: The herbs of Acanthopanax brachypus Harms
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Scutellarein-7-O-glucoside

Catalog No: CFN95082
CAS No: 26046-94-6
Price: $318/10mg
Stevia impurity (13-[(2-O-6-deoxy-...

Catalog No: CFN95229
CAS No: 1309929-72-3
Price: $463/5mg
2-Methoxy-1,4-naphthoquinone

Catalog No: CFN95269
CAS No: 2348-82-5
Price: $70/20mg
Isoeuphorbetin

Catalog No: CFN95207
CAS No: 50677-55-9
Price: $318/5mg
Baishouwubenzophenone

Catalog No: CFN95473
CAS No: 115834-34-9
Price: $318/5mg
New compound 2

Catalog No: CFN95181
CAS No: N/A
Price: $318/5mg
Grosvenorin 2''-glucoside

Catalog No: CFN95282
CAS No: N/A
Price: $318/5mg
Rhamnocitrin 3-apiosyl-(1->2)-gluc...

Catalog No: CFN95145
CAS No: 148031-68-9
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.047 mL 5.2351 mL 10.4701 mL 20.9402 mL 26.1753 mL
5 mM 0.2094 mL 1.047 mL 2.094 mL 4.188 mL 5.2351 mL
10 mM 0.1047 mL 0.5235 mL 1.047 mL 2.094 mL 2.6175 mL
50 mM 0.0209 mL 0.1047 mL 0.2094 mL 0.4188 mL 0.5235 mL
100 mM 0.0105 mL 0.0524 mL 0.1047 mL 0.2094 mL 0.2618 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
J Ethnopharmacol. 2005 Feb 28;97(2):359-67.
Antiinflammatory effects of chiisanoside and chiisanogenin obtained from the leaves of Acanthopanax chiisanensis in the carrageenan- and Freund's complete adjuvant-induced rats.[Pubmed: 15707776]

METHODS AND RESULTS:
To find the antiinflammtory constituents of Acanthopanax chiisanensis (Araliaceae) leaves, Since BuOH extract among the fractionated extracts exhibited the most potent effect, it was subjected to column chromatography to yield a main triterpene glycoside, Chiisanoside (1). This compound was hydrolyzed in alkaline solution to find the biological activity of produced aglycone, chiisanogenin (1a). Oral treatment with Chiisanoside and 1a produced significant antiinflammtory effects at 10 and 30 mg/kg dose, and 1a was more potent than Chiisanoside. The antiiflammtory effects of the two compounds were supported by the reduction of carrageenan-induced lipid peroxidation and hydroxy radical in serum. Furthermore, treatment with Chiisanoside and 1a significantly reduced rheumatoid arthritis (RA) and C-reactive protein (CRP) factors in the rat induced by Freund's complete adjuvant reagent.
CONCLUSIONS:
Compounds, Chiisanoside and 1a, inhibited xanthine oxidase activity and increased superoxide dismutase (SOD), glutathione peroxidase and catalase indicating that both compounds scavenged reactive oxygen species (ROS).
Calycosin

Catalog No: CFN99140
CAS No: 20575-57-9
Price: $80/20mg
Ginsenoside Rg5

Catalog No: CFN92643
CAS No: 186763-78-0
Price: $238/20mg
Neogambogic acid

Catalog No: CFN90175
CAS No: 93772-31-7
Price: $258/20mg
Cineole

Catalog No: CFN90545
CAS No: 470-82-6
Price: $30/20mg
Dauricine

Catalog No: CFN98129
CAS No: 524-17-4
Price: $98/20mg
N1,N10-Bis(p-coumaroyl)spermidine

Catalog No: CFN99248
CAS No: 114916-05-1
Price: $ /
Chicoric acid

Catalog No: CFN99725
CAS No: 6537-80-0
Price: $70/20mg
Crocin

Catalog No: CFN90227
CAS No: 42553-65-1
Price: $40/20mg
11-Oxomogroside III

Catalog No: CFN92192
CAS No: 952481-53-7
Price: $318/10mg
Ginsenoside Rk1

Catalog No: CFN92644
CAS No: 494753-69-4
Price: $188/20mg
Tags: buy Chiisanoside | Chiisanoside supplier | purchase Chiisanoside | Chiisanoside cost | Chiisanoside manufacturer | order Chiisanoside | Chiisanoside distributor