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Clausine Z
Clausine Z
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Clausine Z
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CAS No.: 866111-14-0
Catalog No.: CFN97428
Molecular Formula: C13H9NO3
Molecular Weight: 227.2 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Clausena excavata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Weizmann Institute of Science (Israel)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
Targets: CDK
In vitro:
Pharmazie. 2005 Aug;60(8):637-9.
Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5.[Pubmed: 16124414]

METHODS AND RESULTS:
A new carbazole alkaloid, named Clausine Z, has been isolated from the stems and leaves of Clausena excavata Burm. (Rutaceae). Its structure was established by spectroscopic methods.
CONCLUSIONS:
The compound exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
Clausine Z Description
Source: The herbs of Clausena excavata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.4014 mL 22.007 mL 44.0141 mL 88.0282 mL 110.0352 mL
5 mM 0.8803 mL 4.4014 mL 8.8028 mL 17.6056 mL 22.007 mL
10 mM 0.4401 mL 2.2007 mL 4.4014 mL 8.8028 mL 11.0035 mL
50 mM 0.088 mL 0.4401 mL 0.8803 mL 1.7606 mL 2.2007 mL
100 mM 0.044 mL 0.2201 mL 0.4401 mL 0.8803 mL 1.1004 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN97821Clausine D142846-95-5279.34C18H17NO2
CFN97840Demethylmurrayanine123497-84-7211.22C13H9NO2
CFN91484Murrayanine723-97-7225.2C14H11NO2
CFN91823Clausine E182261-83-2241.2C14H11NO3
CFN97428Clausine Z866111-14-0227.2 C13H9NO3
CFN97800Clausine I182261-94-5241.24C14H11NO3
CFN97796Clauszoline M187110-72-1227.22C13H9NO3
CFN92926Curryangine25488-37-3331.45C23H25NO
CFN92927Murrayamine E172617-68-4347.45C23H25NO2
CFN91189Koenimbine21087-98-9293.4C19H19NO2
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