Clauszoline M | CAS:187110-72-1 | Manufacturer ChemFaces

Clauszoline M

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Clauszoline M shows a significant anti-tuberculosis activity.

Targets:

Antifection

In vitro:

Bioorg Med Chem. 2016 Dec 27. pii: S0968-0896(16)31162-2.

Anti-tuberculosis activity and structure-activity relationships of oxygenated tricyclic carbazole alkaloids and synthetic derivatives.[Pubmed: 28094223 ]

METHODS AND RESULTS:
A series of 49 oxygenated tricyclic carbazole derivatives has been tested for inhibition of the growth of Mycobacterium tuberculosis and a mammalian cell line (vero cells). From this series, twelve carbazoles showed a significant anti-TB activity.
CONCLUSIONS:
The four most active compounds were the naturally occurring carbazole alkaloids Clauszoline M (45), murrayaline C (41), carbalexin C (27), and the synthetic carbazole derivative 22 with MIC90 values ranging from 1.5 to 3.7μM. The active compounds were virtually nontoxic for the mammalian cell line in the concentration range up to 50μM.

Clauszoline M Description

Source:	The herbs of Clausena dunniana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Clauszoline M
Price:
CAS No.:	187110-72-1
Catalog No.:	CFN97796
Molecular Formula:	C₁₃H₉NO₃
Molecular Weight:	227.22 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The herbs of Clausena dunniana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.401 mL	22.0051 mL	44.0102 mL	88.0204 mL	110.0255 mL
5 mM	0.8802 mL	4.401 mL	8.802 mL	17.6041 mL	22.0051 mL
10 mM	0.4401 mL	2.2005 mL	4.401 mL	8.802 mL	11.0026 mL
50 mM	0.088 mL	0.4401 mL	0.8802 mL	1.7604 mL	2.2005 mL
100 mM	0.044 mL	0.2201 mL	0.4401 mL	0.8802 mL	1.1003 mL

CFN97428	Clausine Z	866111-14-0	227.2	C₁₃H₉NO₃
CFN97800	Clausine I	182261-94-5	241.24	C₁₄H₁₁NO₃
CFN97796	Clauszoline M	187110-72-1	227.22	C₁₃H₉NO₃
CFN92926	Curryangine	25488-37-3	331.45	C₂₃H₂₅NO
CFN92927	Murrayamine E	172617-68-4	347.45	C₂₃H₂₅NO₂
CFN91189	Koenimbine	21087-98-9	293.4	C₁₉H₁₉NO₂
CFN70319	Koenigicine	24123-92-0	323.4	C₂₀H₂₁NO₃
CFN92197	Mahanimbine	21104-28-9	331.5	C₂₃H₂₅NO
CFN92198	Isomahanimbine	26871-46-5	331.5	C₂₃H₂₅NO
CFN92199	Mahanine	28360-49-8	347.5	C₂₃H₂₅NO₂