Ganoderol B | CAS:104700-96-1 | Manufacturer ChemFaces

Ganoderol B

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Size /Price /Stock	10 mM * 1 mL in DMSO / $238 / In-stock
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Description:

Ganoderol B is a potent α-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of α-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.

Targets:

Androgen Receptor

In vitro:

Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum

Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum[Pubmed: 21596546]

Abstract α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl(3) extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC(50) of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC(50) of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3,26-diol (Ganoderol B). It was found to have high α-glucosidase inhibition, with an IC(50) of 48.5 μg/ml (119.8 μM). Copyright © 2011 Elsevier GmbH. All rights reserved.

In vivo:

Bioorg Med Chem. 2007 Jul 15;15(14):4966-72. Epub 2007 Apr 25.

The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum.[Pubmed: 17499997]

Ganoderol B with 5alpha-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats. The down-regulation of AR signaling by Ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that Ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer. In conclusion, our result suggests that Ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.

Ganoderol B Description

Source:	The fruiting body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Phytomedicine. 2011 Sep 15;18(12):1053-5.

Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum.[Pubmed: 21596546]

α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl(3) extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC(50) of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC(50) of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3,26-diol (Ganoderol B). It was found to have high α-glucosidase inhibition, with an IC(50) of 48.5 μg/ml (119.8 μM).

Product Name	Ganoderol B
Price:	$318 / 5mg
CAS No.:	104700-96-1
Catalog No.:	CFN99064
Molecular Formula:	C₃₀H₄₈O₂
Molecular Weight:	440.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The fruiting body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antiandrogenic Compound Library Alpha-glucosidase inhibitors Compound Library Triterpenoids Compound Library Androgen Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2691 mL	11.3456 mL	22.6912 mL	45.3823 mL	56.7279 mL
5 mM	0.4538 mL	2.2691 mL	4.5382 mL	9.0765 mL	11.3456 mL
10 mM	0.2269 mL	1.1346 mL	2.2691 mL	4.5382 mL	5.6728 mL
50 mM	0.0454 mL	0.2269 mL	0.4538 mL	0.9076 mL	1.1346 mL
100 mM	0.0227 mL	0.1135 mL	0.2269 mL	0.4538 mL	0.5673 mL

CFN99064	Ganoderol B	104700-96-1	440.7	C₃₀H₄₈O₂
CFN99065	Ganoderol A	104700-97-2	438.7	C₃₀H₄₆O₂
CFN95604	15,26-Dihydroxylanosta-7,9(11),24-trien-3-one	420781-85-7	454.7	C₃₀H₄₆O₃
CFN99244	Ganoderiol F	114567-47-4	454.7	C₃₀H₄₆O₃
CFN99085	Ganodermanondiol	107900-76-5	456.7	C₃₀H₄₈O₃
CFN80461	Ganoderiol A	106518-61-0	474.37	C₃₀H₅₀O₄
CFN99077	Ganodermanontriol	106518-63-2	472.7	C₃₀H₄₈O₄
CFN95617	New compound 25	N/A	470.7	C₃₀H₄₆O₄
CFN90304	Lucialdehyde A	420781-84-6	438.69	C₃₀H₄₆O₂
CFN90306	Ganoderal A	104700-98-3	436.68	C₃₀H₄₄O₂