Complanatoside A | CAS:146501-37-3 | Manufacturer ChemFaces

Complanatoside A

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Description:

Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia.

In vitro:

Biomed Chromatogr. 2016 Jun;30(6):888-93.

Quantification of complanatoside A in rat plasma using LC-MS/MS and its application to a pharmacokinetic study.[Pubmed: 26393341]

Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia.
METHODS AND RESULTS:
For the first time, a simple and sensitive LC-MS/MS method was developed for the determination of Complanatoside A in rat plasma over the range of 2.3-575 ng/mL. Complanatoside A was extracted from plasma by a protein precipitation procedure, separated by LC and detected by MS/MS in positive electrospray ionization mode. The method was validated for selectivity, carryover, sensitivity, linearity, extraction recovery, matrix effect, accuracy, precision and stability studies. The lower limit of quantification was established at 2.3 ng/mL. Intra- and inter-day precisions (LLOQ, low-QC, med-QC and high-QC) were <7.9%, and accuracies were between 94.0 and 105.1%. Matrix effect was acceptable (97.9-103.0%) and extraction recovery was reproducible (88.5-94.4%). Complanatoside A was stable in the investigated conditions.
CONCLUSIONS:
The method was applied to the pharmacokinetics of Complanatoside A in rats.

Complanatoside A Description

Source:	The seeds of Astragalus complanatus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Zhongguo Zhong Yao Za Zhi. 2005 Apr;30(8):600-2.

[Determination of complanatoside A in semen Astragali complanati by HPLC].[Pubmed: 16011285]

To establish the determination method for Complanatoside A in seeds of Astragalus complanatus.
METHODS AND RESULTS:
An HPLC method has been developed to separate Complanatoside A on ZORBAX EXTEND-C18 (4.6 mm x 250 mm, 5 microm) column with acetonitrile-water-phosphoric acid (20:80:0.2) as mobile phase and UV detection at 267 nm. The good linearity of Complanatoside A ranged 0.086-0.430 microg, r = 0.9999. An average recovery of 99.8% (n = 5) was obtained with a RSD of 1.0%.
METHODS AND RESULTS:
The established method is proved to be stability, fast, accurate and can be used for quantification of Complanatoside A in Semen Astragali Complanati.

Product Name	Complanatoside A
Price:
CAS No.:	146501-37-3
Catalog No.:	CFN99525
Molecular Formula:	C₂₇H₃₀O₁₈
Molecular Weight:	642.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The seeds of Astragalus complanatus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Quality control indexes Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5564 mL	7.7821 mL	15.5642 mL	31.1284 mL	38.9105 mL
5 mM	0.3113 mL	1.5564 mL	3.1128 mL	6.2257 mL	7.7821 mL
10 mM	0.1556 mL	0.7782 mL	1.5564 mL	3.1128 mL	3.8911 mL
50 mM	0.0311 mL	0.1556 mL	0.3113 mL	0.6226 mL	0.7782 mL
100 mM	0.0156 mL	0.0778 mL	0.1556 mL	0.3113 mL	0.3891 mL

CFN80126	Myricetin 3-O-beta-D-xylopyranosyl(1-2)-beta-D-glucopyranoside	142449-93-2	612.13	C₂₆H₂₈O₁₇
CFN80330	Myricetin 3-O-beta-D-xylopyranosyl(1-2)-[alpha-L-rhamnopyranosyl-(1-6)]-beta-D-glucopyranoside	N/A	758.63	C₃₂H₃₈O₂₁
CFN95278	Cannabiscitrin	520-14-9	480.4	C₂₁H₂₀O₁₃
CFN99525	Complanatoside A	146501-37-3	642.5	C₂₇H₃₀O₁₈
CFN98387	Mearnsitrin	30484-88-9	478.4	C₂₂H₂₂O₁₂
CFN80175	Laricitrin 3-O-glucoside	39986-90-8	494.10	C₂₂H₂₂O₁₃
CFN90468	Syringetin-3-O-glucoside	40039-49-4	508.43	C₂₃H₂₄O₁₃
CFN70408	Syringetin 3-O-galactoside	55025-56-4	508.4	C₂₃H₂₄O₁₃
CFN91150	Syringetin-3-O-rutinoside	53430-50-5	654.6	C₂₉H₃₄O₁₇
CFN99840	Myricitrin	17912-87-7	464.4	C₂₁H₂₀O₁₂