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Corytuberine
Corytuberine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Corytuberine
Price:
CAS No.: 517-56-6
Catalog No.: CFN90528
Molecular Formula: C19H21NO4
Molecular Weight: 327.37 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Caltha palustris L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Corytuberine was inhibited only by naloxone and that of bulbocapnine preferentially by yohimbine.
In vivo:
Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:255-81.
Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, corytuberine, boldine and glaucine.[Pubmed: 2907279]

METHODS AND RESULTS:
The aporphine alkaloids bulbocapnine, Corytuberine, boldine and glaucine were studied in mice and compared with haloperidol, phenobarbital and morphine. All aporphines inhibited the exploratory rearing activity and elicited palpebral ptosis, catalepsy, hypothermia, and prolonged anesthesia by thiopental. They also reduced nociception (hot plate; phenylquinone-induced writhing) and (except for Corytuberine) were anticonvulsant against harman and picrotoxin, but not against bicuculline and pentetrazol; Corytuberine was proconvulsant. The aporphines (except for Corytuberine) antagonized the apomorphine- and methylphenidate-induced stereotyped gnawing and also the apomorphine-induced climbing activity; Corytuberine was prostereotypic. The antignawing effects (including those of haloperidol) were stronger when the antagonists were administered after the agonists (gnawing full-fletched) rather than before them: this led to the speculation of a metaphilic interaction at central site(s). Clonazepam inhibited the antistereotypic effect (vs apomorphine) more potently with the aporphines than with haloperidol. The antinociceptive effect (writhing) of the aporphines was, in contrast to that of morphine, resistant to both naloxone and yohimbine. The latter applied also to the antilicking action in the hot plate test; the antijumping effect of boldine was (like that of morphine) antagonized by both yohimbine and naloxone, whereas that of Corytuberine was inhibited only by naloxone and that of bulbocapnine preferentially by yohimbine.
METHODS AND RESULTS:
Hence, opioid and adrenergic mechanisms are unequally involved in the antinociceptive effects of the aporphines. The present results also showed that licking and jumping (in the hot plate test) are pharmacologically different phenomena. In low doses, the aporphines and haloperidol antagonized the antinociceptive effect of morphine (hot plate); hence, these drugs may be considered partial agonists or partial antagonists, respectively.
Corytuberine Description
Source: The herbs of Caltha palustris L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0546 mL 15.2732 mL 30.5465 mL 61.093 mL 76.3662 mL
5 mM 0.6109 mL 3.0546 mL 6.1093 mL 12.2186 mL 15.2732 mL
10 mM 0.3055 mL 1.5273 mL 3.0546 mL 6.1093 mL 7.6366 mL
50 mM 0.0611 mL 0.3055 mL 0.6109 mL 1.2219 mL 1.5273 mL
100 mM 0.0305 mL 0.1527 mL 0.3055 mL 0.6109 mL 0.7637 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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CAS No: 82854-37-3
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CAS No: 38243-03-7
Price: $60/20mg
Parishin A

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CAS No: 62499-28-9
Price: $50/20mg
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