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Cotoin
Cotoin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cotoin
Price: $338 / 10mg
CAS No.: 479-21-0
Catalog No.: CFN98729
Molecular Formula: C14H12O4
Molecular Weight: 244.2 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Yellow powder
Source: The herbs of Garcinia cowa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $144.7 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cotoin is a natural product from Garcinia virgata.
Cotoin Description
Source: The herbs of Garcinia cowa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.095 mL 20.475 mL 40.95 mL 81.9001 mL 102.3751 mL
5 mM 0.819 mL 4.095 mL 8.19 mL 16.38 mL 20.475 mL
10 mM 0.4095 mL 2.0475 mL 4.095 mL 8.19 mL 10.2375 mL
50 mM 0.0819 mL 0.4095 mL 0.819 mL 1.638 mL 2.0475 mL
100 mM 0.041 mL 0.2048 mL 0.4095 mL 0.819 mL 1.0238 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry. 2004 Nov;65(21):2915-20.
Prenylated xanthones and tocotrienols from Garcinia virgata.[Pubmed: 15501261 ]

METHODS AND RESULTS:
Two xanthones, namely virgataxanthone A and B, have been isolated from the stem bark of Garcinia virgata, together with two formylated tocotrienols and the known delta-tocotrienol, griffipavixanthone and 2,6-dihydroxy-4-methoxybenzophenone (Cotoin). Their structures were mainly established using one and two-dimensional NMR and mass spectroscopies.
CONCLUSIONS:
When sufficient material was available, the antioxidant activities of the crude extracts as well as the isolated compounds were evaluated.
CFN89497Cearoin52811-37-7244.24C14H12O4
CFN893072,6,4'-Trihydroxy-4-methoxybenzophenone55051-85-9260.24C14H12O5
CFN98836Maclurin519-34-6262.2 C13H10O6
CFN98864Iriflophenone52591-10-3246.2 C13H10O5
CFN97524Dimethylmatairesinol943989-68-2392.4 C19H20O9
CFN99063Iriflophenone 3-C-beta-D-glucopyranoside104669-02-5408.4 C19H20O10
CFN96651Sulochrin519-57-3332.30C17H16O7
CFN96952Monomethylsulochrin10056-14-1346.33C18H18O7
CFN891039-Dehydroxyeurotinone1360606-85-4272.25C15H12O5
CFN980912,2',3'-Trihydroxy-4,6-dimethoxybenzophenone219861-73-1290.3 C15H14O6
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