Curculigoside B | CAS:143601-09-6 | Manufacturer ChemFaces

Curculigoside B

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $206.7 / In-stock
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Description:

Curculigoside B shows antioxidative and antiosteoporotic activities, it can decrease area of bone resorption pit, osteoclastic formation and TRAP activity.

In vitro:

Phytomedicine. 2009 Sep;16(9):874-81.

Antiosteoporotic activity of phenolic compounds from Curculigo orchioides.[Pubmed: 19328665]

Six phenolic compounds isolated from Curculigo orchioides, including 2,6-dimethoxy benzoic acid (1), curculigoside A (2), Curculigoside B (3), curculigine A (4), curculigine D (5) and 3,3',5,5'-tetramethoxy-7,9':7',9-diepoxylignan-4,4'-di-O-beta-D-glucopyranoside (6), together with the ethanol extract of Curculigo orchioides were evaluated for their activity on osteoblasts in neonatal rat calvaria cultures and multinucleated osteoclasts derived from rat marrow cells so as to characterize the antiosteoporotic components of this plant and explore the relationship of chemical structure with antiosteoporotic activity.
METHODS AND RESULTS:
The proliferation of osteoblast was assayed by MTT methods. The activity of ALP (alkaline phosphatase) and TRAP (tartrate-resistant acid phosphatase) was measured by p-nitrophenyl sodium phosphate assay. The TRAP stain was used to identify osteoclast in morphology. The resorption pit area on the bone slices formed by osteoclast was measured by computer image processing. The ethanol extract exhibited stimulatory effect on both the osteoblast proliferation and the ALP activity. Six compounds all increased the osteoblast proliferation, and compounds (1), (2) and (4) also slightly increased the osteoblastic ALP activity. Compounds (1), (2), (3), (6) and the ethanol extract decreased area of bone resorption pit, osteoclastic formation and TRAP activity.
CONCLUSIONS:
These results indicated that phenolic compounds are antiosteoporotic chemical constituents from Curculigo orchioides, and their activities are related with chemical structures.

Curculigoside B Description

Source:	The rhizomes of Curculigo orchioides Gaertn.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1065-7.

Antioxidative phenols and phenolic glycosides from Curculigo orchioides.[Pubmed: 16079552]

A new orcinol glucoside, orcinol-1-O-beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside (3), was isolated from the rhizomes of Curculigo orchioides GAERTN., together with seven known compounds: orcinol glucoside (1), orcinol-1-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside (2), curculigoside (4), Curculigoside B (5), curculigoside C (6), 2,6-dimethoxyl benzoic acid (7), and syringic acid (8).
METHODS AND RESULTS:
The structures of these compounds were elucidated using spectroscopic methods. The antioxidant activities of these isolated compounds were evaluated by colorimetric methods based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively.
CONCLUSIONS:
All the compounds showed potent antioxidative activities and the structure-activity relationship is discussed.

Product Name	Curculigoside B
Price:	$338 / 10mg
CAS No.:	143601-09-6
Catalog No.:	CFN92961
Molecular Formula:	C₂₁H₂₄O₁₁
Molecular Weight:	452.41 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The rhizomes of Curculigo orchioides Gaertn.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2104 mL	11.0519 mL	22.1038 mL	44.2077 mL	55.2596 mL
5 mM	0.4421 mL	2.2104 mL	4.4208 mL	8.8415 mL	11.0519 mL
10 mM	0.221 mL	1.1052 mL	2.2104 mL	4.4208 mL	5.526 mL
50 mM	0.0442 mL	0.221 mL	0.4421 mL	0.8842 mL	1.1052 mL
100 mM	0.0221 mL	0.1105 mL	0.221 mL	0.4421 mL	0.5526 mL

CFN90721	4-Methoxyphenyl beta-D-glucopyranoside	6032-32-2	286.28	C₁₃H₁₈O₇
CFN95574	1-Phenylethyl beta-D-glucoside	93199-03-2	284.3	C₁₄H₂₀O₆
CFN93252	Androsin	531-28-2	328.3	C₁₅H₂₀O₈
CFN91540	Glucovanillin	494-08-6	314.3	C₁₄H₁₈O₈
CFN95427	Benzyl beta-D-glucopyranoside	4304-12-5	270.3	C₁₃H₁₈O₆
CFN95429	2-Phenylethyl-beta-glucopyranoside	18997-54-1	284.3	C₁₄H₂₀O₆
CFN99541	D-(-)-Salicin	138-52-3	286.27	C₁₃H₁₈O₇
CFN90664	Apiopaeonoside	100291-86-9	460.43	C₂₀H₂₈O₁₂
CFN90668	Paeonolide	72520-92-4	460.43	C₂₀H₂₈O₁₂
CFN97203	Henryoside	72021-23-9	584.5	C₂₆H₃₂O₁₅