| In vitro: |
| Bull. Korean Chem. Soc., 2010, 31(4):1081-4. | | Cytotoxic Constituents from the Leaves of Zanthoxylum schinifoliu.[Reference: WebLink] |
METHODS AND RESULTS:
The results showed that the methylene chloride fraction exhibited the strongest MTT cytotoxicity. Chromatographic separation of the methylene chloride and butanol fractions had yielded a quinolin (1), three phenylpropanoids (2, 3, 12), four coumarins (4 ~ 7), three triterpenoids (8 ~ 10), an alkaloid (11), an alcohol glucoside (13) and three monoterpene glucosides (14, 15, 16). One of these compounds were identified as new threo-6-amino-5-hydroxy-5-methyl- 1,3-oxazinan-4-one (11) together with fifteen known, 3-heptyl- 2-methylisoquinolin-1(2H)-one (1), integrifoliodiol (2), Cuspidiol (3), bergapten (4), aurapten (5), 8-hydroxy-7-methoxy- chromen-2-one (6), 6,7-dimethoxy-2H-naphthalen-1-one (7), lupeol (8), lupeone (9), β-sitosterol (10), syringin (12), 2-propyl alchol β-D-glucopyranoside (13), vomifoliol-9-O-β-D-glucopyranoside (14), betulalbuside A (15) and cnidioside C (16) on the basis of spectroscopic and chemical evidences.
CONCLUSIONS:
All of the compounds were isolated for the first time from this plant except 5 and 7. In the MTT cytotoxicity assay against Jurkat T cell clone E6.1, IC50 values of Cuspidiol (3) and auraptene (5) were obtained at 7.3 μg/mL and 16.5 μg/mL, respectively. |
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