Cyclo(Ile-Leu) | CAS:91741-17-2 | Manufacturer ChemFaces

Cyclo(Ile-Leu)

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Description:

Cyclo(Ile-Leu) shows cytotoxic activity in vitro.

In vitro:

《Journal of Shenyang Pharmaceutical University》 2007-08

Cyclic dipeptide constituents from the mangrove fungus Penicillium oxalicum(No.092007)[Reference: WebLink]

To study the metabolites of mangrove fungus Penicillium oxalicum from the south China sea and search for new anti-tumor compounds.
METHODS AND RESULTS:
Compounds were isolated by silica gel,ODS column chromatography,Sephadex LH-20 column chromatography and reversed-phase HPLC purification.Structural elucidation was achieved by physico-chemical constants and spectroscopic analysis MTT assay was used to evaluate the bioactivities in vitro.Six cyclic dipeptides were isolated from the acetone extracts of mycelium of fungus and elucidated as cyclo-(Phe-Ile)(1),cyclo-(Phe-Val)(2),Cyclo(Ile-Leu)(3),cyclo-(Val-Val)(4),cyclo-(Pro-Val)(5),cyclo-(Pro-Gly)(6).Coumpouds 2,3 and 5 could evidently inhibit the growth of cancer cell lines HepG Ⅱ and LNCaP at the concentration of 50 μg·mL-1.
CONCLUSIONS:
All of Compounds are obtained from the marine fungus for the fist time.Compounds 2,Cyclo(Ile-Leu) and 5 show cytotoxic activity in vitro.

Cyclo(Ile-Leu) Description

Source:	From Penicillium oxalicum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cyclo(Ile-Leu)
Price:	$238 / 10mg
CAS No.:	91741-17-2
Catalog No.:	CFN90289
Molecular Formula:	C₁₂H₂₂N₂O₂
Molecular Weight:	226.32 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	From Penicillium oxalicum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.4185 mL	22.0926 mL	44.1852 mL	88.3704 mL	110.4631 mL
5 mM	0.8837 mL	4.4185 mL	8.837 mL	17.6741 mL	22.0926 mL
10 mM	0.4419 mL	2.2093 mL	4.4185 mL	8.837 mL	11.0463 mL
50 mM	0.0884 mL	0.4419 mL	0.8837 mL	1.7674 mL	2.2093 mL
100 mM	0.0442 mL	0.2209 mL	0.4419 mL	0.8837 mL	1.1046 mL

CFN91573	Cyclo(Ala-Val)	15136-26-2	170.2	C₈H₁₄N₂O₂
CFN90284	Cyclo(Ile-Ala)	90821-99-1	184.24	C₉H₁₆N₂O₂
CFN90264	Cyclo(Ile-Val)	104068-43-1	212.29	C₁₁H₂₀N₂O₂
CFN90289	Cyclo(Ile-Leu)	91741-17-2	226.32	C₁₂H₂₂N₂O₂
CFN90283	Cyclo(Leu-Ala)	1803-60-7	184.24	C₉H₁₆N₂O₂
CFN90291	Cyclo(Leu-Val)	5625-50-3	212.29	C₁₁H₂₀N₂O₂
CFN90288	Cyclo(Leu-Leu)	1436-27-7	226.32	C₁₂H₂₂N₂O₂