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Cynatratoside A
Cynatratoside A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cynatratoside A
Price:
CAS No.: 97399-96-7
Catalog No.: CFN96784
Molecular Formula: C28H40O8
Molecular Weight: 504.62 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The roots of Cynanchum paniculatum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cynatratoside A and Cynanversicoside C are therefore potential candidate drugs for use against Ichthyophthirius multifiliis.
Targets: Antifection
In vitro:
Parasitology. 2017 Feb;144(2):179-185.
Activity of two extracts of Cynanchum paniculatum against Ichthyophthirius multifiliis theronts and tomonts.[Pubmed: 27928976]

METHODS AND RESULTS:
The present study aims to evaluate the antiparasitic activity of active components from Cynanchum paniculatum against Ichthyophthirius multifiliis. The antiparasitic activities of two bioassay-guided fractionationated compounds from C. paniculatum identified as Cynatratoside A and Cynanversicoside C, by comparing spectral data (NMR and ESI-MS) with literature values, were evaluated by in vitro assay. These showed that both could kill theronts of I. multifiliis at a concentration of 10·0 mg L-1, with the median effective concentration (EC50) values of 4·6 mg L-1 and 5·2 mg L-1 for Cynatratoside A and Cynanversicoside C, respectively. Encysted tomonts were killed at concentrations of 8·0 mg L-1 with both compounds. In vivo experiments demonstrated that fish treated with both compounds at 15·0 mg L-1 carried significantly fewer parasites than controls (P < 0·05).
CONCLUSIONS:
There were no mortalities among treated fish group compared with 75% mortality of untreated fish. Cynatratoside A and Cynanversicoside C are therefore potential candidate drugs for use against I. multifiliis.
Cynatratoside A Description
Source: The roots of Cynanchum paniculatum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9817 mL 9.9084 mL 19.8169 mL 39.6338 mL 49.5422 mL
5 mM 0.3963 mL 1.9817 mL 3.9634 mL 7.9268 mL 9.9084 mL
10 mM 0.1982 mL 0.9908 mL 1.9817 mL 3.9634 mL 4.9542 mL
50 mM 0.0396 mL 0.1982 mL 0.3963 mL 0.7927 mL 0.9908 mL
100 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.3963 mL 0.4954 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Asian Nat Prod Res. 2016;18(4):339-43.
Two new 13,14:14,15-disecopregnane-type compounds from the roots of Cynanchum paniculatum.[Pubmed: 26465069 ]

METHODS AND RESULTS:
Two new 13,14:14,15-disecopregnane-type compounds glaucogenin F (1), glaucogenin F 3-O-β-D-oleandropyranoside (2), together with three known compounds cynapanoside A (3), Cynatratoside A (4), and neocynapanogenin F 3-O-β-D-oleandropyranoside (5) were isolated from the 95% ethanol extract of the roots of Cynanchum paniculatum.
CONCLUSIONS:
The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses, including 1D and 2D NMR, HRESIMS and NOESY.
CFN91815Cynanoside F1800029-50-8794.9C41H62O15
CFN97496Tenacissoside F928151-78-4668.8 C35H56O12
CFN97605Marsdenoside F858360-61-9752.90C39H60O14
CFN908773-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B1260252-18-3781.0C41H64O14
CFN90428Tenacissoside H191729-45-0794.97C42H66O14
CFN97795Tenacissoside G191729-43-8792.96C42H64O14
CFN97794Tenacissoside I191729-44-9814.97C44H62O14
CFN97890Dregeoside Da198665-65-7815.0C42H70O15
CFN97588Dregeoside Ga198665-66-8941.17C49H80O17
CFN97790Dregeoside Aa120230-41-5939.15C49H78O17
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