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DL-Homocysteic acid
DL-Homocysteic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name DL-Homocysteic acid
Price: $30 / 20mg
CAS No.: 504-33-6
Catalog No.: CFN90077
Molecular Formula: C4H9NO5S
Molecular Weight: 183.18 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source:
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $7.0 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: DL-Homocysteic acid application disrupts calcium homeostasis and induces degeneration of spinal motor neurons in vivo.
Targets: Calcium Channel
In vitro:
J Colloid Interface Sci. 2005 Mar 1;283(1):231-7.
Effect of dl-homocysteic acid on W/O microemulsions of potassium naphthenate/1-octanol-n-heptane.[Pubmed: 15694443]
The effect of DL-Homocysteic acid (DL-2-amino-4-sulfonobutyric acid) on W/O microemulsion of potassium naphthenate (80%) and naphthenic acid (20%) in mixed solvent (1-octanol and n-heptane) has been found in four phases: (1) Interaction between the amino acid molecules and the polar head groups of the surfactant through hydrogen bonding enhances solubilization in the aqueous cores. (2) The interaction results in the growth of the microemulsion droplets and the homogenization of the particle size distribution. (3) The microstructure of the solubilized water remains unchanged, except that the polarity of the interface is affected. (4) The transition point is reduced to lower water content. A possible mechanism is proposed.
In vivo:
Am J Physiol. 1989 Mar;256(3 Pt 2):H688-96.
Cardiorespiratory effects of DL-homocysteic acid in caudal ventrolateral medulla.[Pubmed: 2646953]

METHODS AND RESULTS:
We carried out experiments in urethan-anesthetized rats to determine 1) whether increasing the activity of small groups of neurons in the caudal ventrolateral medulla (CVLM) by injecting picomoles of an excitatory amino acid altered cardiovascular and/or respiratory homeostasis and 2) whether the depressor responses after chemical excitation in the CVLM were elicited only from the immunohistochemically identified catecholamine-containing cell group. In discrete sites in the CVLM, unilateral injections of 1-12 nl (20-240 pmol) of DL-Homocysteic acid (DLH; 20 mM, pH 7.4) selectively or concomitantly inhibited arterial pressure, heart rate, and diaphragm electromyogram (EMG) activity. In the region in which chemical excitation slowed breathing, units were recorded extracellularly that discharged with respiratory periodicity. Sites where the smallest volumes of DLH decreased arterial pressure were located outside the immunohistochemically identified DBH-positive cell bodies.
CONCLUSIONS:
These data suggest that either the same or neighboring neurons in the CVLM are involved in the central neural circuitry for both cardiovascular and respiratory control and that cells other than the catecholaminergic cell group are important in medullary depressor responses.
Acta Neuropathol. 2002 May;103(5):428-36.
DL-Homocysteic acid application disrupts calcium homeostasis and induces degeneration of spinal motor neurons in vivo.[Pubmed: 11935257]
Excitotoxicity, autoimmunity and free radicals have been postulated to play a role in the pathomechanism of amyotrophic lateral sclerosis (ALS), the most frequent motor neuron disease. Altered calcium homeostasis has already been demonstrated in Cu/Zn superoxide dismutase transgenic animals, suggesting a role for free radicals in the pathogenesis of ALS, and in passive transfer experiments, modeling autoimmunity. These findings also suggested that yet-confined pathogenic insults, associated with ALS, could trigger the disruption of calcium homeostasis of motor neurons.
METHODS AND RESULTS:
To test the possibility that excitotoxic processes may also be able to increase calcium in motor neurons, we applied the glutamate analogue DL-Homocysteic acid to the spinal cord of rats in vivo and analyzed the calcium distribution of the motor neurons over a 24-h survival period by electron microscopy. Initially, an elevated cytoplasmic calcium level, with no morphological sign of degeneration, was noticed. Later, increasing calcium accumulation was seen in different cellular compartments with characteristic features of alteration at different survival times. This calcium accumulation in organelles was paralleled by their progressive degeneration, which culminated in cell death by the end of the observation time. These findings confirm that increased calcium also plays a role in excitotoxic lesion of motor neurons, in line with previous studies documenting the involvement of calcium ions in motor neuronal injury in other models of the disease as well as elevated calcium in biopsy samples from ALS patients.
CONCLUSIONS:
We suggest that intracellular calcium might be responsible for the interplay between the different pathogenic processes resulting in a uniform clinicopathological picture of the disease.
DL-Homocysteic acid Description
Source:
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.4591 mL 27.2956 mL 54.5911 mL 109.1822 mL 136.4778 mL
5 mM 1.0918 mL 5.4591 mL 10.9182 mL 21.8364 mL 27.2956 mL
10 mM 0.5459 mL 2.7296 mL 5.4591 mL 10.9182 mL 13.6478 mL
50 mM 0.1092 mL 0.5459 mL 1.0918 mL 2.1836 mL 2.7296 mL
100 mM 0.0546 mL 0.273 mL 0.5459 mL 1.0918 mL 1.3648 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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