| In vitro: |
| Chinese Pharmaceutical Journal,2010,45 (10) :727-32. | | Antitumor Triterpenes from Scorzonera mongolica Maxim[Reference: WebLink] | To study the anti-tumor active constituents of Scorzonera mongolica Maxim..
METHODS AND RESULTS:
The chemical components were isolated by silica gel H,Sephadex LH-20 column chromatography and semi-preparative HPLC.Structures were elucidated on the basis of physicochemical properities and spectral data.The anti-tumor experiment in vitro,the MTT and SRB methods were used to screen constituents of S.mongolica Maxim..15 Triterpenes were isolated and identified as lupeol (1),betulin (2),betulinic acid (3),lupeo acetate (4),23Z-3β-acetoxyeupha-7,23-diene-25-ol (5),Dammaradienyl acetate (6),pulcherryl acetate (7),taraxasterol (8),taraxasteryl acetate (9),ψ-taraxasterol (10),ψ-taraxasteryl acetate (11),α-amyrin acetate (12),dammar-24-ene-3,20-diol,3β-tetradecanoate (13),butyrospermyl acetate (14) and multiflorenyl acetate (15),respectively.
CONCLUSIONS:
Compound 1-15 were obtained from the plant for the first time and compound 2,3,5-15 were obtained from the genus Scorzonera for the first time.Compound 1-5 demonstrated significant inhibitory effects on A-549 cancer cells and compound 14 showed also strong cytotoxity against Bel-7402 cancer cells at the concentration of 50 mg·L-1. |
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