| Structure Identification: |
| Zhongguo Zhong Yao Za Zhi. 2011 Nov;36(22):3134-6. | | Chemical studies on alkaloids of Chinese medicinal herbs Daphniphyllum macropodum.[Pubmed: 22375393] | To study the alkaloids of the Chinese medicinal herbs Daphniphyllum macropodum for in search for new bioactive substances.
METHODS AND RESULTS:
The CHCl3 extract of D. macropodum was subjected to repeated column chromatography on silica gel to afford four pure compounds (1-4). Their structures were determined on the basis of detailed spectroscopic analysis and comparison with the data reported in the literature. The four known compounds were isolated and elucidated as Daphniphyllum alkaloids with different carbon skeletons, namely longistylumphylline A (1), deoxycalyciphylline B (2), daphnicyclidin B (3) and Daphnicyclidin H (4), respectively.
CONCLUSIONS:
All compounds were isolated from the titled plant for the first time. The discovery of daphnicyclidin B (3) and Daphnicyclidin H (4) further confirmed the biogenetic relationship between the two compounds and the previously reported macropodumines A-C, found in the same plant. | | Chem Biodivers. 2006 Nov;3(11):1255-9. | | A zwitterionic alkaloid, containing a rare cyclopentadienyl anion unit, from the stem barks of Daphniphyllum macropodum Miq.[Pubmed: 17193239 ] |
METHODS AND RESULTS:
A new Daphniphyllum alkaloid daphnicyclidin L (1), containing a rare cyclopentadienyl anion, which is stabilized as a zwitterion by an internal iminium counterion, was isolated from the stem barks of Daphniphyllum macropodum Miq., together with four known alkaloids: daphnicyclidin D (2), Daphnicyclidin H (3), deoxyyuzurimine (4), and yuzurimine (5). The structures were elucidated on the basis of spectroscopic data.
CONCLUSIONS:
The configuration of 1 was elucidated by single-crystal X-ray diffraction crystallography. |
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