Daturaolone | CAS:41498-80-0 | Manufacturer ChemFaces

Daturaolone

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Size /Price /Stock	10 mM * 1 mL in DMSO / $370 / In-stock
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Description:

Daturaolone has potency in reducing the harmful effects or in maintaining the normal hepatic physiological mechanisms in both acute and chronic hepato-toxic induced liver damage in rats. Daturaolone also possesses in vivo anti-inflammatory and antinociceptive potentials, which are supported in silico by an interaction with COXs receptors.

Targets:

COX

In vivo:

Evid. Based Complement .Alternat. Med., 2016; 2016: 4098686.

Biological Evaluation and Docking Analysis of Daturaolone as Potential Cyclooxygenase Inhibitor[Reference: WebLink]

This study deals with the isolation of the active constituent(s) from a methanolic extract of Pistacia integerrima J. L. Stewart barks and it was also oriented to evaluate the in vivo and in silico anti-inflammatory activity.
METHODS AND RESULTS:
By NMR and crystallography techniques, we have isolated a triterpenoid identified as Daturaolone (compound 1). This compound showed in vivo a significant and dose dependent (1-30 mg/kg) anti-inflammatory activity on carrageenan induced mouse paw oedema (ED50= 10.1 mg/kg) and on acetic acid-induced writhing responses in mice (ED50= 13.8 mg/kg). In the in vivo experiments, the effect of tested compound was also evaluated in presence of the reference drug diclofenac (1-30 mg/kg). Moreover, in silico analysis of receptor ligand complex shows that compound 1 interacts with cyclooxygenase (COXs) binding sites displaying an interesting interaction with COX-1.
CONCLUSIONS:
These findings suggest that compound 1 isolated from P. integerrima possesses in vivo anti-inflammatory and anti-nociceptive potential, which are supported in silico by an interaction with COXs receptors.

Daturaolone Description

Source:	The herbs of Datura stramonium Linn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Daturaolone
Price:	$390 / 5 mg
CAS No.:	41498-80-0
Catalog No.:	CFN94010
Molecular Formula:	C₃₀H₄₈O₂
Molecular Weight:	440.71 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Datura stramonium Linn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Hepatoprotective Compound Library Anti-nociceptive Compound Library Triterpenoids Compound Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2691 mL	11.3453 mL	22.6907 mL	45.3813 mL	56.7266 mL
5 mM	0.4538 mL	2.2691 mL	4.5381 mL	9.0763 mL	11.3453 mL
10 mM	0.2269 mL	1.1345 mL	2.2691 mL	4.5381 mL	5.6727 mL
50 mM	0.0454 mL	0.2269 mL	0.4538 mL	0.9076 mL	1.1345 mL
100 mM	0.0227 mL	0.1135 mL	0.2269 mL	0.4538 mL	0.5673 mL

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CFN98801	13(18)-Oleanen-3-ol	508-04-3	426.7	C₃₀H₅₀O
CFN98820	delta-Amyrin acetate	51361-60-5	468.8	C₃₂H₅₂O₂
CFN98023	13(18)-Oleanen-3-one	20248-08-2	424.7	C₃₀H₄₈O
CFN96397	Marsformoxide B	2111-46-8	482.8	C₃₂H₅₀O₃
CFN96827	11alpha,12alpha-Oxidotaraxerol palmitate	495389-95-2	679.11	C₄₆H₇₈O₃
CFN93150	Soyasapogenol A	508-01-0	474.7	C₃₀H₅₀O₄
CFN89221	Germanicol	465-02-1	426.72	C₃₀H₅₀O
CFN96961	Germanicol acetate	10483-91-7	468.76	C₃₂H₅₂O₂
CFN99679	beta-Amyrin acetate	1616-93-9	468.8	C₃₂H₅₂O₂