Daurinoline | CAS:2831-75-6 | Manufacturer ChemFaces

Daurinoline

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Description:

Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline.

Targets:

5-HT Receptor | Histamine Receptor | Calcium Channel

In vivo:

《Medical Journal of Wuhan University》 2011-01

Effects of Daurinoline on Microcirculation of Cerebral Pia Mater in Mice[Reference: WebLink]

To investigate the effect of Daurinoline on cerebral pia mater microcirculation in mice.
METHODS AND RESULTS:
An open cranial window was performed and microcirculation disturbance state was established by means of administering noradrenaline on the cerebral pia mater. The effect of Daurinoline was observed from the changes of the diameters and numbers of the arterioles and venules. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline.
CONCLUSIONS:
It suggests that Daurinoline would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury.

Environ Toxicol Pharmacol . 2019 Feb;66:109-115.

Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol[Pubmed: 30641414]

Abstract Non-small cell lung cancer (NSCLC) is one of the most common malignancies, and Taxol is a cornerstone in the treatment. However, taxol-resistance eventually limits the clinical effects and applications. Daurinoline could restore the sensitivity of resistant MCF-7/adr and KBv200 cells. Whereas, the effect of Daurinoline on the chemo-resistant NSCLC cells and the mechanism has not been elucidated. In this study, Daurinoline was firstly demonstrated that inhibited the proliferation, migration, invasion and EMT phenotype of chemo-resistant NSCLC cells. And these effects were associated with EMT and Notch-1 reversal. Moreover, Daurinoline could significantly enhance the anti-tumor effect of Taxol rather than epirubicin, adriamycin and cisplatin. And the reverse fold (RF) value of Daurinoline was greater than terfenadine reported before. There are little cytotoxic effects of Daurinoline and its derivatives reported by L.W. Fu, et al. (2001). Therefore, Daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC patients. Keywords: Chemosensitization; Daurinoline; EMT; Non-small cell lung cancer.

Daurinoline Description

Source:	The roots of Euchresta japonica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

《Herald of Medicine》 2014-06

Relaxant Effect of Daurinoline on Vascular Smooth Muscle of Isolated Rabbit Basilar Artery[Reference: WebLink]

To investigate the effect of Daurinoline on basilar artery vascular smooth muscle.
METHODS AND RESULTS:
The tension of isolated basilar artery ring of rabbit was measured. The effects of Daurinoline on the basilar artery contracted by methoxamine,5-hydroxytryptamine(5-HT),KCl and Histamine( His) were also examined. Dose-response curves of 5-HT and KCl were observed as well. Daurinoline exerted obvious relaxation effect on the basilar artery vascular ring contracted by methoxamine,5-HT,KCl and His in a concentration-dependent manner. IC50of Daurinoline in methoxamine,5-HT,KCl and His-treated rabbits was 8. 67 × 10- 5,1. 78 × 10- 6,6. 79 × 10- 7and 4. 98 × 10- 4mol · L- 1,respectively. The change of concentration-response curves of methoxamine,5-HT,KCl and His showed that Daurinoline was a non-competitive antagonist.
CONCLUSIONS:
Daurinoline exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism. The mechanism of relaxation action may be related to blockage of voltage-dependent or receptor-dependent calcium channels.

Product Name	Daurinoline
Price:
CAS No.:	2831-75-6
Catalog No.:	CFN90601
Molecular Formula:	C₃₇H₄₂N₂O₆
Molecular Weight:	610.7 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Euchresta japonica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Vasorelaxation Compound Library Anti-cerebral ischemia Compound Library Alkaloids Compound Library Histamine Receptor Inhibitor Library Calcium Channel Inhibitor Library 5-HT Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6375 mL	8.1873 mL	16.3747 mL	32.7493 mL	40.9366 mL
5 mM	0.3275 mL	1.6375 mL	3.2749 mL	6.5499 mL	8.1873 mL
10 mM	0.1637 mL	0.8187 mL	1.6375 mL	3.2749 mL	4.0937 mL
50 mM	0.0327 mL	0.1637 mL	0.3275 mL	0.655 mL	0.8187 mL
100 mM	0.0164 mL	0.0819 mL	0.1637 mL	0.3275 mL	0.4094 mL

CFN99574	Isoliensinine	6817-41-0	610.75	C₃₇H₄₂N₂O₆
CFN99578	Liensinine perchlorate	2385-63-9	711.20	C₃₇H₄₂N₂O₆.ClHO₄
CFN99579	Liensinine diperchlorate	5088-90-4	811.67	C₃₇H₄₂N₂O₆.(HClO₄)₂
CFN99580	Liensinine	2586-96-1	610.75	C₃₇H₄₂N₂O₆
CFN99581	Neferine	2292-16-2	624.77	C₃₈H₄₄N₂O₆
CFN90534	Daurisoline	70553-76-3	610.73	C₃₇H₄₂N₂O₆
CFN90601	Daurinoline	2831-75-6	610.7	C₃₇H₄₂N₂O₆
CFN98129	Dauricine	524-17-4	624.77	C₃₈H₄₄N₂O₆
CFN89429	Thalirugidine	64215-95-8	670.79	C₃₉H₄₆N₂O₈
CFN90334	Emetine Hydrochloride	14198-59-5	517.1	C₂₉H₄₁ClN₂O₄