Dehydroandrographolide succinate | CAS:786593-06-4

Dehydroandrographolide succinate

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $14.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Neobavaisoflavone

Catalog No: CFN92222
CAS No: 41060-15-5
Price: $60/20mg

Magnoflorine

Catalog No: CFN98071
CAS No: 2141-09-5
Price: $98/20mg

Quercetin-3-O-sophoroside

Catalog No: CFN90630
CAS No: 18609-17-1
Price: $80/20mg

Ganoderic acid X

Catalog No: CFN92996
CAS No: 86377-53-9
Price: $463/5mg

Pectolinarin

Catalog No: CFN99727
CAS No: 28978-02-1
Price: $118/20mg

Albiflorin

Catalog No: CFN99774
CAS No: 39011-90-0
Price: $50/20mg

L-Alanine

Catalog No: CFN70145
CAS No: 56-41-7
Price: $30/20mg

Isorhynchophylline

Catalog No: CFN96197
CAS No: 6859-01-4
Price: $138/20mg

Oleanolic acid

Catalog No: CFN98800
CAS No: 508-02-1
Price: $30/20mg

(+)-Borneol

Catalog No: CFN70111
CAS No: 464-43-7
Price: $30/20mg

Description:

Dehydroandrographolide succinate can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS. It combined with ribavirin treatedchildren with hand-foodand mouth disease,the duration of fever was shorter,rashes on hands and feet more quickyly.

Targets:

NOS | TNF-α | IL recepter | SOD | Antifection

In vivo:

Anhui Medical Journal, 2010.

Therapeutic effects of dehydroandrographolide succinate combined with ribavirin on children with hand-foot-and-mouth disease[Reference: WebLink]

To evaluate the therapeutic effects of Dehydroandrographolide succinate and ribavirin on children with the early severe tendencies of hand-foot-and-mouth disease.
METHODS AND RESULTS:
Children(46 cases) with the early tendencies of hand-foot-and-mouth disease were divided randomly into two groups.All cases received ribavirin and therapies based on their symptoms,while the treatment group of 23 children received Dehydroandrographolide succinate(10 mg.kg-1.d-1) for 5 days.Clinical symptom regression time or recovery time in two groups were observed after treatments. All children were recovered after treatments and no case develop into neurogenic pulmonary edema or cardiopulmonary collapse.The duration of fever was shorter in the treatment group;rashes on hands and feet faded more quickly than those of the control group.The difference between the two groups had statistical significance.However,there was no statistically significant differences between the two groups as for the time of mental improvement,disappearance of body shaking and hospital stay time.
CONCLUSIONS:
Dehydroandrographolide succinate combined with ribavirin treatedchildren with hand-foodand mouth disease,the duration of fever was shorter,rashes on hands and feet more quickyly.

Dehydroandrographolide succinate Description

Source:	The herbs of Andrographis paniculata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1238-41.

Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS.[Pubmed: 22985554]

To investigate the effect of Dehydroandrographolide succinate (DAS) on oxidative stress and induced nitric oxide synthase (iNOS) expression in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury.
METHODS AND RESULTS:
Thirty male BALB/C mice were randomly divided into control group, LPS+DAS group and LPS group (n=10). The levels of interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), malondialdehyde (MDA) and superoxide dismutase (SOD) in the bronchoalveolar lavage fluid (BALF) were measured. The wet-to-dry ratio (W/D) of the lung tissue was determined to evaluate lung edema. HE staining was used to observe the pathological changes and lung injury scores. The expressions of iNOS mRNA and protein in the lungs were analyzed using RT-PCR and Western blotting, respectively. IL-1β, IL-6, TNF-α and MDA levels in the BALF, W/D, lung injury scores, and iNOS mRNA and protein expressions increased and SOD in the BALF decreased significantly after intratracheal LPS injection. Compared with those in LPS group, IL-1β, IL-6, TNF-α and MDA in BALF, W/D, lung injury scores and iNOS mRNA and protein expression were significantly reduced and SOD in the BALF significantly increased in LPS+DAS group.
CONCLUSIONS:
Dehydroandrographolide succinate can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.

Product Name	Dehydroandrographolide succinate
Price:	$40 / 20mg
CAS No.:	786593-06-4
Catalog No.:	CFN91114
Molecular Formula:	C₂₈H₃₆O₁₀
Molecular Weight:	532.59 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Andrographis paniculata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library TNF-α Inhibitor Library SOD Inhibitor Library NOS Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8776 mL	9.3881 mL	18.7762 mL	37.5523 mL	46.9404 mL
5 mM	0.3755 mL	1.8776 mL	3.7552 mL	7.5105 mL	9.3881 mL
10 mM	0.1878 mL	0.9388 mL	1.8776 mL	3.7552 mL	4.694 mL
50 mM	0.0376 mL	0.1878 mL	0.3755 mL	0.751 mL	0.9388 mL
100 mM	0.0188 mL	0.0939 mL	0.1878 mL	0.3755 mL	0.4694 mL

CFN98908	2',4'-Dihydroxy-3',6'-dimethoxydihydrochalcone	54299-52-4	302.3	C₁₇H₁₈O₅
CFN96242	Akuammidine	639-36-1	352.4	C₂₁H₂₄N₂O₃
CFN99233	1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid	113558-03-5	504.7	C₃₀H₄₈O₆
CFN97600	Andropanolide	869807-57-8	350.45	C₂₀H₃₀O₅