Delta-9-Tetrahydrocannabinolic acid | CAS:23978-85-0

Delta-9-Tetrahydrocannabinolic acid

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Description:

Delta-9-Tetrahydrocannabinolic acid can protect dopaminergic neurons against MPP(+) induced cell death.

In vitro:

Phytomedicine. 2012 Jun 15;19(8-9):819-24.

Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures.[Pubmed: 22571976 ]

Cannabinoids derived from Cannabis sativa demonstrate neuroprotective properties in various cellular and animal models. Mitochondrial impairment and consecutive oxidative stress appear to be major molecular mechanisms of neurodegeneration.
METHODS AND RESULTS:
Therefore we studied some major cannabinoids, i.e. Delta-9-Tetrahydrocannabinolic acid (THCA), delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in mice mesencephalic cultures for their protective capacities against 1-methyl-4-phenyl pyridinium (MPP(+)) toxicity. MPP(+) is an established model compound in the research of parkinsonism that acts as a complex I inhibitor of the mitochondrial respiratory chain, resulting in excessive radical formation and cell degeneration. MPP(+) (10 μM) was administered for 48 h at the 9th DIV with or without concomitant cannabinoid treatment at concentrations ranging from 0.01 to 10 μM. All cannabinoids exhibited in vitro antioxidative action ranging from 669 ± 11.1 (THC), 16 ± 3.2 (THCA) to 356 ± 29.5 (CBD) μg Trolox (a vitamin E derivative)/mg substance in the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay. Cannabinoids were without effect on the morphology of dopaminergic cells stained by tyrosine hydroxylase (TH) immunoreaction. THC caused a dose-dependent increase of cell count up to 17.3% at 10 μM, whereas CBD only had an effect at highest concentrations (decrease of cell count by 10.1-20% at concentrations of 0.01-10 μM). It influenced the viability of the TH immunoreactive neurons significantly, whereas THCA exerts no influence on dopaminergic cell count. Exposure of cultures to 10 μM of MPP(+) for 48 h significantly decreased the number of TH immunoreactive neurons by 44.7%, and shrunken cell bodies and reduced neurite lengths could be observed. Concomitant treatment of cultures with cannabinoids rescued dopaminergic cells. Compared to MPP(+) treated cultures, THC counteracted toxic effects in a dose-dependent manner. THCA and CBD treatment at a concentration of 10 μM lead to significantly increased cell counts to 123% and 117%, respectively.
CONCLUSIONS:
Even though no significant preservation or recovery of neurite outgrowth to control values could be observed, our data show that cannabinoids THC and THCA protect dopaminergic neurons against MPP(+) induced cell death.

Delta-9-Tetrahydrocannabinolic acid Description

Source:	The herbs of Cannabis sativa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Delta-9-Tetrahydrocannabinolic acid
Price:
CAS No.:	23978-85-0
Catalog No.:	CFN91872
Molecular Formula:	C₂₂H₃₀O₄
Molecular Weight:	358.47 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Cannabis sativa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7896 mL	13.9482 mL	27.8963 mL	55.7927 mL	69.7408 mL
5 mM	0.5579 mL	2.7896 mL	5.5793 mL	11.1585 mL	13.9482 mL
10 mM	0.279 mL	1.3948 mL	2.7896 mL	5.5793 mL	6.9741 mL
50 mM	0.0558 mL	0.279 mL	0.5579 mL	1.1159 mL	1.3948 mL
100 mM	0.0279 mL	0.1395 mL	0.279 mL	0.5579 mL	0.6974 mL

CFN96627	Tetrahydrocannabivarin	31262-37-0	286.41	C₁₉H₂₆O₂
CFN89010	10-O-Ethylcannabitriol	1259515-25-7	374.52	C₂₃H₃₄O₄
CFN98793	Rhododendrol	501-96-2	166.2	C₁₀H₁₄O₂
CFN97735	Olivetol	500-66-3	180.24	C₁₁H₁₆O₂
CFN98002	11-Dehydroxygrevilloside B	197307-49-6	342.4	C₁₇H₂₆O₇
CFN97044	4-(3,4-Dihydroxyphenyl)-2-butanone	61152-62-3	180.2	C₁₀H₁₂O₃
CFN97183	4-(3,4-Dimethoxyphenyl)-3-buten-1-ol	69768-97-4	208.3	C₁₂H₁₆O₃
CFN99692	4-(3,4-Dimethoxyphenyl)-3-butene-1,2-diol	164661-12-5	224.3	C₁₂H₁₆O₄
CFN96471	Turmeronol A	131651-37-1	232.32	C₁₅H₂₀O₂