Demethyl tetrandrine | CAS:33889-68-8 | Manufacturer ChemFaces

Demethyl tetrandrine

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Size /Price /Stock	10 mM * 1 mL in DMSO / $15.4 / In-stock
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Description:

Demethyl tetrandrine and tetrandrine show inhibition on DNA synthesis, the 50% inhibition doses ( ID50 ) are in L7712 and Sl80 cells are 27.5, 24.5 mg/L and 2.6, 3 .5mg/ L , respectively.

Targets:

DNA/RNA Synthesis

In vitro:

《Chinese Pharmacological Bulletin》 1990-01

INHIBITION OF TETRANDRINE AND DEMETHYL TETRANDRINE ON DNA, RNA AND PROTEIN SYNTHESES OF LEUKEMIA 7712 AND SARCOMA 180 CELLS[Reference: WebLink]

METHODS AND RESULTS:
The 50% inhibition doses ( ID50 ) of tetrandrine and Demethyl tetrandrine on DNA synthesis in L7712 and Sl80 cells are 2.6, 3 .5mg/ L and 27.5, 24.5mg/L respectively. The DNA synthesis inhibition is likely due to DNA template damage caused by both natural products. The inhibition of DNA, RNA and protein syntheses by tetrandrine or Demethyl tetrandrine increased with incubating time. The inhibiting activities of two natural products on DNA and RNA synthesis are s-tronger than on protein.
CONCLUSIONS:
There are no differences either in inhibiting activity or in inhibiting mechanism between two natural products.

Demethyl tetrandrine Description

Source:	The roots of Stephania tetrandra S.Moore.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Demethyl tetrandrine
Price:	$30 / 20mg
CAS No.:	33889-68-8
Catalog No.:	CFN90482
Molecular Formula:	C₃₇H₄₀N₂O₆
Molecular Weight:	608.72 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Stephania tetrandra S.Moore.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	DNA damaging agents Compound Library Alkaloids Compound Library DNA/RNA Synthesis Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6428 mL	8.214 mL	16.4279 mL	32.8558 mL	41.0698 mL
5 mM	0.3286 mL	1.6428 mL	3.2856 mL	6.5712 mL	8.214 mL
10 mM	0.1643 mL	0.8214 mL	1.6428 mL	3.2856 mL	4.107 mL
50 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.6571 mL	0.8214 mL
100 mM	0.0164 mL	0.0821 mL	0.1643 mL	0.3286 mL	0.4107 mL

CFN98722	Isotetrandrine	477-57-6	622.8	C₃₈H₄₂N₂O₆
CFN98727	Berbamine	478-61-5	608.7	C₃₇H₄₀N₂O₆
CFN99166	Tetrandrine	518-34-3	622.76	C₃₈H₄₂N₂O₆
CFN89488	Thalidezine	18251-36-0	638.74	C₃₈H₄₂N₂O₇
CFN89519	Hernandezine	6681-13-6	652.77	C₃₉H₄₄N₂O₇
CFN99167	Fangchinoline	436-77-1	608.71	C₃₇H₄₀N₂O₆
CFN90532	(-)-Curine	436-05-5	594.69	C₃₆H₃₈N₂O₆
CFN90482	Demethyl tetrandrine	33889-68-8	608.72	C₃₇H₄₀N₂O₆
CFN89510	Thalrugosidine	33954-34-6	638.74	C₃₈H₄₂N₂O₇
CFN97190	Isotetrandrine N-2'-oxide	70191-83-2	638.8	C₃₈H₄₂N₂O₇