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Desoxygambogenin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Desoxygambogenin
Price: $318 / 10mg
CAS No.: 173614-93-2
Catalog No.: CFN92088
Molecular Formula: C38H48O6
Molecular Weight: 600.8 g/mol
Purity: >95%
Type of Compound: Miscellaneous
Physical Desc.: Oil
Source: The herbs of Garcinia hanburyi Hook. f.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $251.2 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Desoxygambogenin is a cytotoxic xanthone, it has anti-HIV-1 activity.
Targets: HIV
In vitro:
Planta Med. 2007 Jan;73(1):33-40. Epub 2006 Nov 21.
Cytotoxic and anti-HIV-1 caged xanthones from the resin and fruits of Garcinia hanburyi.[Pubmed: 17117343]
Three new caged xanthones, 7-methoxydesoxymorellin (1), 2-isoprenylforbesione (2) and 8,8a-epoxymorellic acid (3), together with nine known caged xanthones were isolated from the EtOAc extracts of resin and fruits of Garcinia hanburyi.
METHODS AND RESULTS:
The structures were determined by spectroscopic methods. Most of the isolated compounds showed significant cytotoxicities against a panel of mammalian cancer cell lines. Compound 3, together with the known compounds desoxymorellin, morellic acid, gambogic acid, hanburin, forbesione and dihydroisomorellin, exhibited anti-HIV-1 activity in the reverse transcriptase (RT) assay while the known compounds Desoxygambogenin and dihydroisomorellin were found moderately active in the syncytium assay.
CONCLUSIONS:
This work represents the first report on the anti-HIV-1 activities of caged xanthones.
Desoxygambogenin Description
Source: The herbs of Garcinia hanburyi Hook. f.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6644 mL 8.3222 mL 16.6445 mL 33.2889 mL 41.6112 mL
5 mM 0.3329 mL 1.6644 mL 3.3289 mL 6.6578 mL 8.3222 mL
10 mM 0.1664 mL 0.8322 mL 1.6644 mL 3.3289 mL 4.1611 mL
50 mM 0.0333 mL 0.1664 mL 0.3329 mL 0.6658 mL 0.8322 mL
100 mM 0.0166 mL 0.0832 mL 0.1664 mL 0.3329 mL 0.4161 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry. 1996 Feb;41(3):815-20.
Cytotoxic xanthones from Garcinia hanburyi.[Pubmed: 8835458]

METHODS AND RESULTS:
Eleven novel cytotoxic xanthones, gambogin, morellin dimethyl acetal, isomoreollin B, moreollic acid, gambogenic acid, gambogenin, isogambogenin, Desoxygambogenin, gambogenin dimethyl acetal, gambogellic acid and hanburin were isolated together with four known xanthones, gambogic acid, isomorellin, morellic acid and desoxymorellin, from the dry latex of Garcinia hanburyi. The structures were elucidated by a detailed spectroscopic analysis.
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