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Dichotomin
Dichotomin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Dichotomin
Price:
CAS No.: 53093-47-3
Catalog No.: CFN90703
Molecular Formula: C57H94O26
Molecular Weight: 1195.34 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The rhizomes of Paris yunnanensis Franch.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Reference standards.
Dichotomin Description
Source: The rhizomes of Paris yunnanensis Franch.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.8366 mL 4.1829 mL 8.3658 mL 16.7316 mL 20.9146 mL
5 mM 0.1673 mL 0.8366 mL 1.6732 mL 3.3463 mL 4.1829 mL
10 mM 0.0837 mL 0.4183 mL 0.8366 mL 1.6732 mL 2.0915 mL
50 mM 0.0167 mL 0.0837 mL 0.1673 mL 0.3346 mL 0.4183 mL
100 mM 0.0084 mL 0.0418 mL 0.0837 mL 0.1673 mL 0.2091 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
《Chinese Journal of Natural Medicines》 2009-05
Biotransformation of Dichotomin by Pectinex BE XXL[Reference: WebLink]
To study of structural modification in steroidal saponin by biotransformation technology.
METHODS AND RESULTS:
Structural modification was carried out of glycosyl residues of Dichotomin at C-3 position by Pectinex BE XXL(PBX).Cytotoxicity against HL-60 cells of all products was investigated. The PBX could hydrolyze the glycosyl residues of Dichotomin one-by-one to produce nine transformed compounds.The transformed product(mixture) and four secondary spirostanosides among them exhibited cytotoxicity.Compounds P5,P6 and P7 with α-1,2 end-rhamnosyl residues showed a potential cytotoxic effect on HL-60 cells;P8 with α-1,4 end-rhamnosyl residue had a weak effect on HL-60 cells.Dichotomin,secondary furostanosides and aglycone were not cytotoxic.
CONCLUSIONS:
PBX has various hydrolyzation to the glycosidic bonds of Dichotomin.Nine obtained transformed compounds widen steroidal saponin library.Meanwhile,screening activity affords data for further pharmacological study.
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CFN90704Parisyunnanoside B945865-37-21016.0C50H80O21
CFN90694Pseudoprotodioscin102115-79-71031.18C51H82O2
CFN95345Dioscoreside C1061.2C52H84O22
CFN95346Dioscoreside E435321-73-61077.2C52H84O23
CFN90822Terrestrosin K193605-07-11079.2C51H82O24
CFN90705Pseudoproto Pb102100-46-91177.4C57H92O25
CFN90692Officinalisinin I57944-18-0921.07C45H76O19
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