Digiferruginol | CAS:24094-45-9 | Manufacturer ChemFaces

Digiferruginol

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Size /Price /Stock	10 mM * 1 mL in DMSO / $222.6 / In-stock
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Description:

Digiferruginol has cytotoxic activity. Digiferruginol and hederagenin show weak effect on porcine respiratory and reproductive syndrome virus (PRRSV) with an IC50 value of 80.5 ± 16.9 uM(SI = 19.9) and 43.2 ± 7.4 uM (SI = 13.1), respectively.

Targets:

Antifection

In vitro:

J. Braz. Chem. Soc., 2012, 23(10):1925-32.

Chemical constituents from Chirita longgangensis var. hongyao with inhibitory activity against porcine respiratory and reproductive syndrome virus[Reference: WebLink]

METHODS AND RESULTS:
The structures of the new compounds were elucidated by detailed analysis from NMR (nuclear magnetic resonance) and MS (mass spectrometry) data, and the absolute configuration of chiritalone A was determined by single crystal X-ray diffraction analysis using the Flack parameter. The inhibitory activity of compounds against porcine respiratory and reproductive syndrome virus (PRRSV) was measured by the cytopathic effect (CPE) method.
CONCLUSIONS:
Digiferruginol and hederagenin showed weak effect on PRRSV with an IC50 value of 80.5 ± 16.9 μmol L-1 (SI = 19.9) and 43.2 ± 7.4 μmol L-1 (SI = 13.1), respectively.

Digiferruginol Description

Source:	The roots of Rubia cordifolia L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Nat Prod. 1985 Nov-Dec;48(6):948-51.

Antitumor agents, 75. Synthesis of cytotoxic anthraquinones digiferruginol and morindaparvin-B.[Pubmed: 3841556]

A simple and efficient synthesis of Digiferruginol (4) and morindaparvin-B (10) is described.
METHODS AND RESULTS:
Marschalk reaction of 1-hydroxyanthraquinone afforded 1-hydroxy-2-methylanthraquinone (2). Treatment of 2 with N-bromosuccinimide and benzoyl peroxide led to 1-hydroxy-2-bromomethylanthraquinone (3), which was converted to 4 with AgNO3 in quantitative yield. Methylation of 1,5-dihydroxyanthraquinone yielded a dimethyl ether (6), which was partially demethylated with boron trifluoride to a difluoroboron chelate (7). Treatment of 7 with alkaline HCHO and sodium dithionate gave rise to 1-hydroxy-2-hydroxy-methyl-5-methoxyanthraquinone (9). Cleavage of the 5-methyl ether of 9 with boron tribromide furnished 10.

Product Name	Digiferruginol
Price:	$318 / 5mg
CAS No.:	24094-45-9
Catalog No.:	CFN92536
Molecular Formula:	C₁₅H₁₀O₄
Molecular Weight:	254.2 g/mol
Purity:	>=98%
Type of Compound:	Anthraquinones
Physical Desc.:	Powder
Source:	The roots of Rubia cordifolia L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antiviral Compound Library Cytotoxic Compound Library Anthraquinones Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.9339 mL	19.6696 mL	39.3391 mL	78.6782 mL	98.3478 mL
5 mM	0.7868 mL	3.9339 mL	7.8678 mL	15.7356 mL	19.6696 mL
10 mM	0.3934 mL	1.967 mL	3.9339 mL	7.8678 mL	9.8348 mL
50 mM	0.0787 mL	0.3934 mL	0.7868 mL	1.5736 mL	1.967 mL
100 mM	0.0393 mL	0.1967 mL	0.3934 mL	0.7868 mL	0.9835 mL

CFN92567	1-Hydroxy-2-methylanthraquinone	6268-09-3	238.2	C₁₅H₁₀O₃
CFN92558	1,2-dihydroxy-3-methyl-anthracene-9,10-dione	602-63-1	254.2	C₁₅H₁₀O₄
CFN92109	Digitolutein	477-86-1	268.3	C₁₆H₁₂O₄
CFN97227	Rubiadin 1-methyl ether	7460-43-7	268.3	C₁₆H₁₂O₄
CFN99270	Rubiadin	117-02-2	254.2	C₁₅H₁₀O₄
CFN80213	Lucidin	478-08-0	270.05	C₁₅H₁₀O₅
CFN92112	2-Hydroxy-3-(hydroxymethyl)anthraquinone	68243-30-1	254.2	C₁₅H₁₀O₄
CFN92536	Digiferruginol	24094-45-9	254.2	C₁₅H₁₀O₄
CFN92570	Tectoquinone	84-54-8	222.2	C₁₅H₁₀O₂
CFN99810	2-Hydroxy-3-methylanthraquinone	17241-40-6	238.2	C₁₅H₁₀O₃