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Epifriedelanol acetate
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Product Name Epifriedelanol acetate
Price:
CAS No.: 2259-07-6
Catalog No.: CFN98223
Molecular Formula: C32H54O2
Molecular Weight: 470.8 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Vitis trifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Epifriedelanol exhibits antibacterial activities. It also can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases. Epifriedelanol and friedelin possess promising antioxidant activity, and they are active against the two cancer cells (human T4 lymphoblastoid (CEM-SS) and human cervical (HeLa) cancer cells) with IC50 values ranging from 3.54 to11.45 ug/ml.
Targets: Antifection
In vitro:
Industrial Crops & Products, 2015, 74:752-8.
Antifungal, antibacterial and anticancer activities of Ficus drupacea L. stem bark extract and biologically active isolated compounds[Reference: WebLink]
Seven biochemical compounds from stem bark extracts including β-amyrin (1), β-sitosterol-3-O-β-D-glucopyranoside (2), 5-O-methyllatifolin (3), oleanolic acid (4), epifriedelanol (Epifriedelanol acetate,5), friedelin (6) and epilupeol acetate (7) were isolated and identified.
METHODS AND RESULTS:
Of all the seven compounds, the compounds 3 and 7 exhibited the highest antifungal and antibacterial activities against screened microorganisms. Aspergillus versicolor and A. ochraceus were the most sensitive microorganisms to the isolated compounds whereas Candida albicans was the most resistant fungus. Compounds 4, 5, and 6 did not exhibit much variation in their antibacterial activities except against Staphylococcus aureus and Escherichia coli. The most sensitive bacterium to isolated compounds was Bacillus cereus whereas the most resistant one was Enterobacter cloacae. However, compounds 4, 6 and 7 exhibited the highest antiproliferative activities against most cancer cells.
CONCLUSIONS:
The study reveal that F. drupacea stem barks contain several compounds that have antimicrobial activities against diverse human pathogenic, food and agricultural microbes as well as anticancer activities against human cancer cells of HeLa, MCF-7, Jurkat, HT-29 and T24. These results may guide the search for new natural products with chemotherapeutic attributes.
Pak J Pharm Sci. 2013 Mar;26(2):245-50.
Phenolic contents, antioxidant and cytotoxic activities of Elaeocarpus floribundus Blume.[Pubmed: 23455191]
Elaeocarpus floribundus is higher plant that has been used as traditional medicine for treating several diseases. There is no previous report on phytochemicals and bioactivity studies of this species.
METHODS AND RESULTS:
In this investigation, triterpenoids friedelin, epifriedelanol(Epifriedelanol acetate) and β-sitosterol were isolated from its leaves and stem bark. Determination of total phenolic content of methanolic extract of leaves and stem bark was carried out using Folin-Ciocalteu reagent. All extracts and isolated compounds were subjected to screening of antioxidant activity using DPPH free radical scavenging method and cytotoxic activities by MTT assay towards human T4 lymphoblastoid (CEM-SS) and human cervical (HeLa) cancer cells. In the total phenolic content determination, methanolic extract of leaves gave higher value of 503.08±16.71 mg GAE/g DW than stem bark with value of 161.5±24.81 mg GAE/g DW. Polar extracts of leaves and stem bark possessed promising antioxidant activity with methanol extract of stem bark exhibited strongest activity with IC50 value of 7.36±0.01 μg/ml.
CONCLUSIONS:
In the cytotoxic activity assay, only chloroform extract of leaves showed significant activity with IC50 value of 25.6±0.06 μg/ml against CEM-SS cancer cell, while friedelin and epifriedelanol were found to be active against the two cancer cells with IC50 values ranging from 3.54 to 11.45 μg/ml.
Epifriedelanol acetate Description
Source: The herbs of Vitis trifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.124 mL 10.6202 mL 21.2404 mL 42.4809 mL 53.1011 mL
5 mM 0.4248 mL 2.124 mL 4.2481 mL 8.4962 mL 10.6202 mL
10 mM 0.2124 mL 1.062 mL 2.124 mL 4.2481 mL 5.3101 mL
50 mM 0.0425 mL 0.2124 mL 0.4248 mL 0.8496 mL 1.062 mL
100 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.4248 mL 0.531 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
Planta Med. 2011 Mar;77(5):441-9.
Epifriedelanol from the root bark of Ulmus davidiana inhibits cellular senescence in human primary cells.[Pubmed: 21049397 ]
Since cellular senescence involves organismal aging as well as diverse diseases, aging intervention might contribute to inhibit the aging process as well as aging-associated diseases.
METHODS AND RESULTS:
We tried to search for effective compounds from the root bark of ULMUS DAVIDIANA that are able to inhibit cellular senescence in human fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs). Twenty-two compounds from the root bark of U. DAVIDIANA were isolated and screened for their inhibitory effects on adriamycin-induced cellular senescence by measuring senescence-associated β-galatosidase (SA- β-gal) activity. Among twenty-two compounds isolated, epifriedelanol (Epifriedelanol acetate,3), ssioriside (15), and catechin-7-O- β-D-glucopyranoside (22) had inhibitory effects on adriamycin-induced cellular senescence in HDFs. Friedelin (2), epifriedelanol (3), and catechin-7-O- β-apiofuranoside (18) were active in HUVECs. In particular, epifriedelanol (3) suppressed adriamycin-induced cellular senescence as well as replicative senescence in HDFs and HUVECs.
CONCLUSIONS:
These results suggest that epifriedelanol (3) reduces cellular senescence in human primary cells and might be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases.
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