Eriosemation | CAS:162616-72-0 | Manufacturer ChemFaces

Eriosemation

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Description:

Eriosemation significant androgen receptor (AR) inhibition activity, suggests that it could be a promising candidate for further evaluation for prostate cancer prevention or management.

Targets:

Androgen Receptor

In vitro:

Sci Rep. 2017 May 16;7(1):1955.

Structure Based docking studies towards exploring potential anti-androgen activity of selected phytochemicals against Prostate Cancer.[Pubmed: 28512306 ]

Prostate cancer (PCa) is the second most common malignancy amongst men worldwide. Under PCa maintenance therapy drugs acting as antagonists/partial agonists of hormone receptors against the prostate tissue are used in clinical practices. Prominent drugs being Cyproterone acetate, Flutamide, Bicalutamide, they not only cause acute and long-term toxicity, but also develops drug resistance among patients.Our focus has been on phytochemicals which do not exhibit any cytotoxicity and have significant androgen receptor (AR) inhibition activity.
METHODS AND RESULTS:
As Protein- Ligand interactions play a key role in structure based drug design, so by using molecular docking, we screened 803 phytochemicals and investigated their binding affinity against AR. The three dimensional (3D) structure of AR was retrieved from Protein Data Bank, and docked with 3D Pubchem structures of 803 phytochemicals using Argus Lab. Molecular docking and drug likeness studies were made using ADMET properties while Lipinski's rule of five was performed for the phytochemicals to evaluate their anti-prostate cancer activity.
CONCLUSIONS:
The results showed that Isobavachin exhibited best binding affinity of -13.73 kcal/mol with AR followed by Glabranin, Anthocyanin and Eriosemation. Our studies therefore reveal that these four phytochemicals could be promising candidates for further evaluation for PCa prevention or management.

Eriosemation Description

Source:	The roots of Lupinus luteus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Eriosemation
Price:
CAS No.:	162616-72-0
Catalog No.:	CFN92835
Molecular Formula:	C₁₉H₂₂O₄
Molecular Weight:	314.4 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Lupinus luteus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-androgen receptor Compound Library Anti-prostatic disease Compound Library Flavonoids Compound Library Androgen Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1807 mL	15.9033 mL	31.8066 mL	63.6132 mL	79.5165 mL
5 mM	0.6361 mL	3.1807 mL	6.3613 mL	12.7226 mL	15.9033 mL
10 mM	0.3181 mL	1.5903 mL	3.1807 mL	6.3613 mL	7.9517 mL
50 mM	0.0636 mL	0.3181 mL	0.6361 mL	1.2723 mL	1.5903 mL
100 mM	0.0318 mL	0.159 mL	0.3181 mL	0.6361 mL	0.7952 mL

CFN89191	3,5,7-Trihydroxychromone	31721-95-6	194.14	C₉H₆O₅
CFN92552	Eriosematin A	175448-02-9	246.3	C₁₄H₁₄O₄
CFN92835	Eriosemation	162616-72-0	314.4	C₁₉H₂₂O₄
CFN97949	Maltol	118-71-8	126.1	C₆H₆O₃
CFN95641	5-Hydroxymaltol 3-O-beta-D-glucoside	N/A	304.3	C₁₂H₁₆O₉
CFN94478	Kojic acid	501-30-4	142.11	C₆H₆O₄
CFN94111	Chelidonic acid	99-32-1	184.10	C₇H₄O₆
CFN97716	Demethoxycapillarisin	61854-36-2	286.24	C₁₅H₁₀O₆
CFN96209	Demethoxy-7-O-methylcapillarisin	61854-37-3	300.3	C₁₆H₁₂O₆
CFN90317	Capillarisin	56365-38-9	316.26	C₁₆H₁₂O₇