Filixic acid ABA | CAS:38226-84-5 | Manufacturer ChemFaces

Filixic acid ABA

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Description:

Filixic acid ABA exhibits inhibitory effects on neuraminidase of influenza virus H5N1 with IC50 as 29.57 ± 2.48 uM, it may have anti-influenza virus activity.

Targets:

Influenza virus

In vitro:

Phytochemistry,2012,80: 115–122.

Unusual terpenylated acylphloroglucinols from Dryopteris wallichiana[Reference: WebLink]

METHODS AND RESULTS:
Four unusual terpenylated acylphloroglucinols were isolated from the diethyl ether extract of the scales and rhizomes of the fern Dryopteris wallichiana together with the known compounds albaspidins AA and AB, and Filixic acid ABA and filixic acid ABB. Structures of the isolated compounds were established by extensive spectroscopic analysis and their absolute configuration at C-14″ was determined by comparing their CD spectra with those simulated for the respective isomers.
CONCLUSIONS:
Pure acylphloroglucinols displayed moderate in vitro nematocidal activity against L4 stage larvae of Nippostrongylus brasiliensis (LD50 = 22–121 μM).

Molecules. 2017 Mar 8;22(3). pii: E431.

Anti-Influenza Virus (H5N1) Activity Screening on the Phloroglucinols from Rhizomes of Dryopteris crassirhizoma.[Pubmed: 28282885 ]

For screening the active phloroglucinols on influenza virus (H5N1) from Dryopteris crassirhizoma NaKai, a database was established including twenty-three phloroglucinols that had been isolated from Dryopteris crassirhizoma.
METHODS AND RESULTS:
Their inhibitory effect on the neuraminidase (NA) of influenza virus H5N1 was screened by molecular docking. As a result, three candidates were selected. The rhizomes of D. crassirhizoma were subjected to isolation and purification processes to obtain the inhibitor candidates. Thirteen phloroglucinols were obtained, including three selected candidates and two new phloroglucinols. The five phloroglucinols were investigated for their inhibitory activity on NA in vitro. The results showed that dryocrassin ABBA and Filixic acid ABA exhibited inhibitory effects on NA with IC50 as 18.59 ± 4.53 and 29.57 ± 2.48 μM, respectively, and the other three phloroglucinols showed moderate inhibitory activity. Moreover, the anti-influenza virus (H5N1) activity and cytotoxicity of dryocrassin ABBA and Filixic acid ABA were tested on Madin-Darby canine kidney (MDCK) cells with the cell counting kit-8 (CCK8) method. The results confirmed that dryocrassin ABBA exhibited an inhibitory activity with low cytotoxicity (TC50 > 400 μM) against influenza virus (H5N1) which will have to be investigated in further detail.
CONCLUSIONS:
In conclusion, phloroglucinols from D. crassirhizoma were shown to have anti-influenza virus activity, and especially dryocrassin ABBA, one of the phloroglucinols, may have the potential to control influenza virus (H5N1) infection.

Filixic acid ABA Description

Source:	The rhizomes of Dryopteris crassirhizoma Nakai
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Filixic acid ABA
Price:
CAS No.:	38226-84-5
Catalog No.:	CFN99573
Molecular Formula:	C₃₂H₃₆O₁₂
Molecular Weight:	612.63 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Yellow powder
Source:	The rhizomes of Dryopteris crassirhizoma Nakai
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antiviral Compound Library Phenols Compound Library Influenza virus Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6323 mL	8.1615 mL	16.3231 mL	32.6461 mL	40.8077 mL
5 mM	0.3265 mL	1.6323 mL	3.2646 mL	6.5292 mL	8.1615 mL
10 mM	0.1632 mL	0.8162 mL	1.6323 mL	3.2646 mL	4.0808 mL
50 mM	0.0326 mL	0.1632 mL	0.3265 mL	0.6529 mL	0.8162 mL
100 mM	0.0163 mL	0.0816 mL	0.1632 mL	0.3265 mL	0.4081 mL

CFN92877	Didemethylpseudoaspidin AA	142382-28-3	376.4	C₁₉H₂₀O₈
CFN90684	Pseudoaspidin	478-28-4	460.5	C₂₅H₃₂O₈
CFN98474	Albaspidin AA	3570-40-9	404.4	C₂₁H₂₄O₈
CFN90252	Albaspidin AP	59092-91-0	418.44	C₂₂H₂₆O₈
CFN99573	Filixic acid ABA	38226-84-5	612.63	C₃₂H₃₆O₁₂
CFN98169	Agrimol B	55576-66-4	682.75	C₃₇H₄₆O₁₂
CFN99519	Dryocrassin ABBA	12777-70-7	820.81	C₄₃H₄₈O₁₆
CFN90561	Gossypol	303-45-7	518.56	C₃₀H₃₀O₈
CFN98529	Acetate gossypol	12542-36-8	578.61	C₃₂H₃₄O₁₀
CFN99601	Sideroxylonal A	145382-68-9	500.5	C₂₆H₂₈O₁₀