Gancaonin I | CAS:126716-36-7 | Manufacturer ChemFaces

Gancaonin I

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $312.8 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Gancaonin I exhibits anti-BsFtsZ GTPase activities; it also shows significant inhibitory activity against B. subtilis, with a MIC value of 5 uM.

Targets:

Antifection | GTPase

In vitro:

Bioorg Med Chem Lett. 2017 Mar 15;27(6):1420-1424.

Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.[Pubmed: 28196701]

FtsZ is an essential protein for bacterial cell division, and an attractive and underexploited novel antibacterial target protein.
METHODS AND RESULTS:
Screening of Indonesian plants revealed the inhibitory activity of the methanol extract of Glycyrrhiza glabra on the Bacillus subtilis FtsZ (BsFtsZ) GTPase, and further bioassay-guided fractionation of the active methanol extract led to the isolation of seven known polyketides (1-7). Among them, Gancaonin I (1), glycyrin (3), and isolicoflavanol (5) exhibited anti-BsFtsZ GTPase activities, at levels comparable to that of the synthetic FtsZ inhibitor, Zantrin Z3. Enzymatic assays using a BsFtsZ Val307R mutant protein and in silico simulations suggested that 1, 3, and 5 bind to the cleft on BsFtsZ, as in the case of the previously reported uncompetitive FtsZ inhibitor, PC190723, and thereby display their significant anti-BsFtsZ inhibitory activities. Furthermore, 1 also showed significant inhibitory activity against B. subtilis, with a MIC value of 5μM.
CONCLUSIONS:
The present study provides new insights into the naturally occurring B. subtilis growth inhibitors.

Gancaonin I Description

Source:	The roots of Glycyrrhiza glabra.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Gancaonin I
Price:	$368 / 5mg
CAS No.:	126716-36-7
Catalog No.:	CFN96842
Molecular Formula:	C₂₁H₂₂O₅
Molecular Weight:	354.40 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The roots of Glycyrrhiza glabra.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antibacterial Compound Library Phenols Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8217 mL	14.1084 mL	28.2167 mL	56.4334 mL	70.5418 mL
5 mM	0.5643 mL	2.8217 mL	5.6433 mL	11.2867 mL	14.1084 mL
10 mM	0.2822 mL	1.4108 mL	2.8217 mL	5.6433 mL	7.0542 mL
50 mM	0.0564 mL	0.2822 mL	0.5643 mL	1.1287 mL	1.4108 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	0.5643 mL	0.7054 mL

CFN91749	N-Phenethylbenzamide	3278-14-6	225.29	C₁₅H₁₅NO
CFN90044	Corticosterone	50-22-6	346.46	C₂₁H₃₀O₄
CFN91082	Bacopaside X	94443-88-6	899.08	C₄₆H₇₄O₁₇
CFN96820	8beta-(4-Hydroxytigloyloxy)ovatifolin	554449-27-3	404.45	C₂₂H₂₈O₇