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Gomisin L1
Gomisin L1
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Gomisin L1
Price:
CAS No.: 82425-43-2
Catalog No.: CFN96734
Molecular Formula: C22H26O6
Molecular Weight: 386.44 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The fruits of Schizandra chinensis BAILL.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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Related Libraries
Biological Activity
Description: (-)-Gomisin L1 induces G2/M arrest and apoptosis in human ovarian cancer cells.
In vitro:
International Journal of Molecular Medicine, 2015, 36:S57-S57.
(-)-Gomisin L1 isolated from Schisandra Chinensis fruit induces G2/M arrest and apoptosis in human ovarian cancer cells[Reference: WebLink]
(-)-Gomisin L1 isolated from Schisandra Chinensis fruit induces G2/M arrest and apoptosis in human ovarian cancer cells.
Gomisin L1 Description
Source: The fruits of Schizandra chinensis BAILL.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5877 mL 12.9386 mL 25.8772 mL 51.7545 mL 64.6931 mL
5 mM 0.5175 mL 2.5877 mL 5.1754 mL 10.3509 mL 12.9386 mL
10 mM 0.2588 mL 1.2939 mL 2.5877 mL 5.1754 mL 6.4693 mL
50 mM 0.0518 mL 0.2588 mL 0.5175 mL 1.0351 mL 1.2939 mL
100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.5175 mL 0.6469 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chemical & Pharmaceutical Bulletin, 1982, 30(1):132-139
The Constituents of Schizandra chinensis Baill. X. The Structures of .GAMMA.-schizandrin and four new lignans,(-)-gomisins L1 and L2,(.+-.)-gomisin M1 and (+)-gomisin M2.[Reference: WebLink]

METHODS AND RESULTS:
Four new dibenzocyclooctadiene lignans, named (-)-Gomisin L1 (6) and (-)-gomisin L2 (7), (±)-gomisin M1 (8) and (+)-gomisin M2 (9), were isolated from the fruits of Schizandra chinensis BAILL. (Schizandraceae). Their absolute structures were elucidated by means of chemical and spectral studies.
CONCLUSIONS:
The stereostructure of γ-schizandrin (1, dl-form), the plane structure of which had already been suggested by Kochetkov et al. and Liu et al., was also elucidated on the basis of chemical and spectral studies.
CFN92724Schisanlignone D144606-84-8398.4C22H22O7
CFN92841Schisandrin C epoxide81345-36-0398.4C22H22O7
CFN92278Rubrisandrin A919289-30-8388.5C22H28O6
CFN99922Schizandrin A61281-38-7416.51C24H32O6
CFN99012Schisandrol A7432-28-2432.5C24H32O7
CFN92722Schisanlignone A135557-67-4430.5C24H30O7
CFN90125Gomisin N69176-52-9400.46C23H28O6
CFN99923Schizandrin B61281-37-6400.47C23H28O6
CFN98990Gomisin A58546-54-6416.5 C23H28O7
CFN97309R(+)-Gomisin M182467-50-3386.4 C22H26O6
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