Gymnestrogenin | CAS:19942-02-0 | Manufacturer ChemFaces

Gymnestrogenin

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Size /Price /Stock	10 mM * 1 mL in DMSO / $218 / In-stock
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Description:

Gymnestrogenin has a dual LXRα/β antagonistic profile.

Targets:

Liver X Receptor

In vitro:

Steroids. 2015 Apr;96:121-31.

Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists.[Pubmed: 25668616 ]

The individual chemical components of commercial extract of Gymnema sylvestre, a medicinal plant used in the traditional systems of the Indian medicine for its antidiabetic and hypolipidemic properties, were isolated and evaluated for their capability to act as modulators of nuclear and membrane receptors involved in glucose and lipid homeostasis.
METHODS AND RESULTS:
The study disclosed for the first time that individual gymnemic acids are potent and selective antagonists for the β isoform of LXR. Indeed the above activity was shared by the most abundant aglycone gymnemagenin (10) whereas Gymnestrogenin (11) was endowed with a dual LXRα/β antagonistic profile. Deep pharmacological investigation demonstrated that Gymnestrogenin, reducing the expression of SREBP1c and ABCA1 in vitro, is able to decrease lipid accumulation in HepG2 cells.
CONCLUSIONS:
The results of this study substantiate the use of G. sylvestre extract in LXR mediated dislypidemic diseases.

Gymnestrogenin Description

Source:	The leaves of Gymnema sylvestre.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Gymnestrogenin
Price:	$268 / 5mg
CAS No.:	19942-02-0
Catalog No.:	CFN90966
Molecular Formula:	C₃₀H₅₀O₅
Molecular Weight:	490.72 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The leaves of Gymnema sylvestre.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antagonists Compound Library Triterpenoids Compound Library Liver X Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0378 mL	10.1891 mL	20.3782 mL	40.7564 mL	50.9455 mL
5 mM	0.4076 mL	2.0378 mL	4.0756 mL	8.1513 mL	10.1891 mL
10 mM	0.2038 mL	1.0189 mL	2.0378 mL	4.0756 mL	5.0946 mL
50 mM	0.0408 mL	0.2038 mL	0.4076 mL	0.8151 mL	1.0189 mL
100 mM	0.0204 mL	0.1019 mL	0.2038 mL	0.4076 mL	0.5095 mL

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CFN91068	Soyasapogenol C	595-14-2	440.7	C₃₀H₄₈O₂
CFN91069	Soyasapogenol D	65892-76-4	472.8	C₃₁H₅₂O₃
CFN99870	Melilotigenin C	188970-21-0	456.7	C₃₀H₄₈O₃
CFN97479	Melilotigenin B	91269-84-0	454.7	C₃₀H₄₆O₃
CFN98704	alpha-Boswellic acid	471-66-9	456.7	C₃₀H₄₈O₃
CFN90529	3-O-Acetyl-alpha-boswellic acid	89913-60-0	498.74	C₃₂H₅₀O₄
CFN95916	3-O-Acetyl-11-methoxy-alpha-boswellic acid	1619260-05-7	528.8	C₃₃H₅₂O₅
CFN96343	Beta-Peltoboykinolic acid	24778-48-1	456.7	C₃₀H₄₈O₃
CFN98004	Erythrodiol 3-palmitate	19833-13-7	681.1	C₄₆H₈₀O₃