Gypenoside L | CAS:94987-09-4 | Manufacturer ChemFaces

Gypenoside L

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Size /Price /Stock	10 mM * 1 mL in DMSO / $348.8 / In-stock
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Description:

Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also possesses non-small cell lung carcinoma A549 cell inhibitory activity.

Targets:

ROS | Calcium Channel

In vitro:

Archives of Pharmacal Research, 2013, 36(7):874-879.

Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells.[Reference: WebLink]

METHODS AND RESULTS:
An ethanol extract from heat-processed Gynostemma pentaphyllum showed more potent cytotoxic activity against human lung adenocarcinoma A549 cells than that of raw G. pentaphyllum. Four constituents were isolated from heat-processed G. pentaphyllum using resin HP-20, silica gel and reversed ODS column chromatography. They were identified by mass and NMR spectra as damulin A and damulin B, Gypenoside L and Gypenoside LI, respectively. To evaluate the efficacy of these four constituents, the MTT cytotoxicity assay was performed using A549 cells.
CONCLUSIONS:
Based on the structure of these four constituents, the results indicate that the hydroxyl group in C-2 and double bond in C20(21) and C20(22) positions are of importance in inhibition of A549 cell proliferation.

Gypenoside L Description

Source:	The herbs of Gynostemma pentaphyllum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Oncotarget, 2016, 7(30):47387-47402.

Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.[Reference: WebLink]

Esophageal cancer is one of the leading cause of cancer mortality in the world. Due to the increased drug and radiation tolerance, it is urgent to develop novel anticancer agent that triggers nonapoptotic cell death to compensate for apoptosis resistance.
METHODS AND RESULTS:
In this study, we show that treatment with Gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, induced nonapoptotic, lysosome-associated cell death in human esophageal cancer cells. Gyp-L-induced cell death was associated with lysosomal swelling and autophagic flux inhibition. Mechanistic investigations revealed that through increasing the levels of intracellular reactive oxygen species (ROS), Gyp-L triggered protein ubiquitination and endoplasm reticulum (ER) stress response, leading to Ca2+ release from ER inositol trisphosphate receptor (IP3R)-operated stores and finally cell death. Interestingly, there existed a reciprocal positive-regulatory loop between Ca2+ release and ER stress in response to Gyp-L. In addition, protein synthesis was critical for Gyp-L-mediated ER stress and cell death.
CONCLUSIONS:
Taken together, this work suggested a novel therapeutic option by Gyp-L through the induction of an unconventional ROS-ER-Ca2+-mediated cell death in human esophageal cancer.

Structure Identification:

Journal of the Agricultural Chemical Society of Japan, 2014, 78(2):311-316

Determination by UPLC-MS of four dammarane-type saponins from heat-processed Gynostemma pentaphyllum.[Reference: WebLink]

Heat-processed Gynostemma pentaphyllum and its main dammaran-type saponins, Gypenoside L, Gypenoside LI, damulin B, and damulin A, possess non-small cell lung carcinoma A549 cell inhibitory activity.
METHODS AND RESULTS:
We established in this study a method by ultra-high performance liquid chromatography with tandem mass spectrometry for determination of the saponins and also investigated their content change in heat-processed G. pentaphyllum.
CONCLUSIONS:
The main saponins increased with increasing heating temperature and time. Further investigation showed that they were produced from gypenoside XLVI and Gypenoside LVI by undergoing hydrolysis during the heat treatment.

Product Name	Gypenoside L
Price:	$268 / 5mg
CAS No.:	94987-09-4
Catalog No.:	CFN91854
Molecular Formula:	C₄₂H₇₂O₁₄
Molecular Weight:	801.0 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Gynostemma pentaphyllum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library ROS Inhibitor Library Calcium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2484 mL	6.2422 mL	12.4844 mL	24.9688 mL	31.211 mL
5 mM	0.2497 mL	1.2484 mL	2.4969 mL	4.9938 mL	6.2422 mL
10 mM	0.1248 mL	0.6242 mL	1.2484 mL	2.4969 mL	3.1211 mL
50 mM	0.025 mL	0.1248 mL	0.2497 mL	0.4994 mL	0.6242 mL
100 mM	0.0125 mL	0.0624 mL	0.1248 mL	0.2497 mL	0.3121 mL

CFN90340	20(R)-Ginsenoside Rh2	112246-15-8	622.88	C₃₆H₆₂O₈
CFN95749	12-Methoxyginsenoside Rh2	N/A	652.9	C₃₇H₆₄O₉
CFN99969	Ginsenoside Rg3	14197-60-5	785.02	C₄₂H₇₂O₁₃
CFN98170	20(R)-Ginsenoside Rg3	38243-03-7	785.02	C₄₂H₇₂O₁₃
CFN95750	12-Methoxyginsenoside Rg3	N/A	799.1	C₄₃H₇₄O₁₃
CFN95748	25-Methoxyginsenoside Rg3	2977279-15-3	817.1	C₄₃H₇₆O₁₄
CFN95763	20-Methoxyginsenoside Rg3	N/A	799.1	C₄₃H₇₄O₁₃
CFN92813	Ginsenoside Rs3	194861-70-6	827.1	C₄₄H₇₄O₁₄
CFN90859	Notoginsenoside Ft1	155683-00-4	917.2	C₄₇H₈₀O₁₇
CFN95860	Notoginsenoside ST4	155683-02-6	917.2	C₄₇H₈₀O₁₇