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Heudelotinone
Heudelotinone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Heudelotinone
Price:
CAS No.: 133453-58-4
Catalog No.: CFN99415
Molecular Formula: C18H20O2
Molecular Weight: 268.4 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Yellow powder
Source: The branches of Jatropha carcas L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Heudelotinone shows cytotoxicity against three cancer cell lines A549, Hela, and SMMC-7721( IC50 values of 16.04, 10.67 and 21.68 uM , respectively).
In vitro:
Helv.Chim.Acta, 2011, 94(5):842-6.
A New Tetracyclic Diterpene from Jatropha curcas[Reference: WebLink]

METHODS AND RESULTS:
Jatrophodione A (1), a new diterpene with four rings, together with nine known compounds, caniojane (2), jatropholone A (3), jatropholone B (4), jatrogrossidione (5), 2-epijatrogrossidione (6), Heudelotinone (7), gossweilone (8), (3α)-3-hydroxy-ent-pimara-8(14),15-dien-12-one (9), and 12-hydroxy-13-methylpodocarpa-8,11,13-trien-3-one (10), was isolated from the aerial parts of Jatropha curcas. Compounds 5, 6, 9, and 10 were found for the first time in this plant. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1, 2, 7, 8, and 9 were tested on the three cancer cell lines A549, Hela, and SMMC-7721.
CONCLUSIONS:
Results showed that 7 exhibited cytotoxicity against SMMC-7721 with an IC50 value of 21.68 μM, whereas 7 and 8 were active against A549 with the IC50 values of 16.04 and 20.47 μM, and against Hela with the IC50 values of 10.67 and 22.83 μM, respectively.
Heudelotinone Description
Source: The branches of Jatropha carcas L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7258 mL 18.6289 mL 37.2578 mL 74.5156 mL 93.1446 mL
5 mM 0.7452 mL 3.7258 mL 7.4516 mL 14.9031 mL 18.6289 mL
10 mM 0.3726 mL 1.8629 mL 3.7258 mL 7.4516 mL 9.3145 mL
50 mM 0.0745 mL 0.3726 mL 0.7452 mL 1.4903 mL 1.8629 mL
100 mM 0.0373 mL 0.1863 mL 0.3726 mL 0.7452 mL 0.9314 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chem Pharm Bull (Tokyo). 2004 May;52(5):608-11.
New lathyrane and podocarpane diterpenoids from Jatropha curcas.[Pubmed: 15133216]

METHODS AND RESULTS:
Chemical investigation on Jatropha curcas resulted in the isolation of twenty constituents among which four diterpenoids were unknown and six compounds, tetradecyl-(E)-ferulate, 3-O-(Z)-coumaroyl oleanolic acid, Heudelotinone, epi-isojatrogrossidione, 2alpha-hydroxy-epi-isojatrogrossidione, and 2-methyanthraquinone had not been reported earlier from this species.
CONCLUSIONS:
The structures of the new compounds were established by extensive studies of their 1D- and 2D-NMR spectra.
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