| In vitro: |
| Biol Pharm Bull. 2004 Sep;27(9):1471-5. | | HIV-1 inhibitory compounds from Calophyllum brasiliense leaves.[Pubmed: 15340243 ] |
METHODS AND RESULTS:
The hexane, acetone and methanol extracts of Calophyllum brasiliense leaves were fractionated following a three bioassay guide: high HIV-1 RT inhibition, low cytotoxicity on MT2 cells and high inhibition of HIV-1 IIIb/LAV replication. This led to the isolation of three anti HIV-1 dipyranocoumarins: calanolides A and B and soulattrolide. In contrast, other isolated compounds such as apetalic acid, Isoapetalic acid, a structural isomer of Isoapetalic acid, friedelin, canophyllol and amentoflavone were devoid of HIV-1 RT inhibitory activity.
CONCLUSIONS:
Calanolide C was also obtained as a natural product and showed moderate inhibitory properties. | | Nat.Prod. 2016, 10(5):649-53. | | Cytotoxic and Antibacterial Activities of Constituents from Calophyllum ferrugineum Ridley[Reference: WebLink] |
METHODS AND RESULTS:
This study evaluated the chemical composition of Calophyllum ferrugineum, cytotoxicity against human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines as well as antibacterial activities against two Gram-positive bacteria, S. aureus and B. subtilis and two Gram-negative bacteria, P. aeruginosa and E. coli. Phytochemical investigations of the bark extract yielded Isoapetalic acid (1), apetalic acid (2), 6-hydroxy-2-methoxyxanthone (3) and ent-epicatechin (4). Meanwhile, betulinic acid (5), protocatechuic acid (6) and amentoflavone (7) were isolated from the leave extract. Isoapetalic acid (1) and apetalic acid (2) exhibited cytotoxic activities towards both cancer cell lines and both Gram-positive bacteria. Compounds (3-7) were inactive or showed moderate activities towards cytotoxic and antibacterial tests.
CONCLUSIONS:
This study presents the first report on the phytochemicals investigation from C. ferrugineum and all compounds are reported for the first time from this source. |
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