Science | Nature | Cell | View More
Natural Products
Isoerysenegalensein E
Isoerysenegalensein E
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Isoerysenegalensein E
Price:
CAS No.: 478158-77-9
Catalog No.: CFN96071
Molecular Formula: C25H26O6
Molecular Weight: 422.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The herbs of Erythrina indica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Griffith University (Australia)
  • Florida International University (USA)
  • University Medical Center Mainz (Germany)
  • University of Beira Interior (Portugal)
  • Johannes Gutenberg University M... (Germany)
  • University of Parma (Italy)
  • Guangzhou Institutes of Biomedi... (China)
  • Fraunhofer-Institut für Moleku... (Germany)
  • Siksha O Anusandhan University (India)
  • Korea Intitute of Science and T... (Korea)
  • Korea Institute of Oriental Med... (Korea)
  • More...
Package
Featured Products
Secologanic acid

Catalog No: CFN95028
CAS No: 60077-46-5
Price: $318/20mg
Costunolide

Catalog No: CFN98928
CAS No: 553-21-9
Price: $40/20mg
Napellonine

Catalog No: CFN90393
CAS No: 509-24-0
Price: $218/20mg
Croceic acid

Catalog No: CFN90226
CAS No: 27876-94-4
Price: $60/20mg
Quercetin-3-o-rutinose

Catalog No: CFN92447
CAS No: 949926-49-2
Price: $ / mg
Syringin

Catalog No: CFN99282
CAS No: 118-34-3
Price: $80/20mg
Vaccarin

Catalog No: CFN90131
CAS No: 53452-16-7
Price: $30/20mg
Secoxyloganin

Catalog No: CFN98996
CAS No: 58822-47-2
Price: $118/20mg
8-Hydroxypinoresinol

Catalog No: CFN92432
CAS No: 81426-17-7
Price: $ / mg
Ganoderic acid K

Catalog No: CFN92057
CAS No: 104700-95-0
Price: $318/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, which is triggered by mitochondrial dysfunction.
Targets: Caspase | Estrogen receptor | Progestogen receptor
In vitro:
Planta Med. 2006 Apr;72(5):424-9.
Induction of apoptosis by isoflavonoids from the leaves of Millettia taiwaniana in human leukemia HL-60 cells.[Pubmed: 16557456]

METHODS AND RESULTS:
We have isolated two new isoflavonoids, millewanin-F (1) and furowanin-A (2), together with five known isoflavonoids from the leaves of Millettia taiwaniana Hayata (Leguminosae) and examined their effects on the growth of human leukemia HL-60 cells. Among the isolated isoflavonoids, furowanin-A (2), warangalone (3), isoerysenegalensein-E (4), and euchrenone b10 (6) showed significant cytotoxicity against HL-60 cells. After treatment with three of the cytotoxic isoflavonoids, furowanin-A (2), warangalone (3), and Isoerysenegalensein E (4), fluorescence microscopy with Hoechst 33,342 staining revealed that the percentage of apoptotic cells with fragmented nuclei and condensed chromatin increased in a time-dependent manner. In addition, the activities of caspase-9 and caspase-3 were also enhanced in a time-dependent manner upon treatment with the isoflavonoids 2, 3, and Isoerysenegalensein E. Caspase-9 and caspase-3 inhibitors suppressed apoptosis induced by isoflavonoids 2, 3, and Isoerysenegalensein E.
CONCLUSIONS:
These results suggest that the isoflavonoids induced apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, which is triggered by mitochondrial dysfunction.
Journal of Health Science, 2006 , 52 (2) :186-191.
AntiEstrogenic Activity of Prenylated Isoflavones from Millettia pachycarpa: Implications for Pharmacophores and Unique Mechanisms[Reference: WebLink]
Phytoestrogens containing isoflavonoids are thought to exhibit preventative effects on estrogen-responsive diseases. Chemical modifications, such as prenylation, in biosynthetic processes enhance the structural variety of isoflavonoids and prompted us to carry out a structure-activity relationship study.
METHODS AND RESULTS:
We determined the estrogenic/anti-estrogenic activities and estrogen receptor (ER)-binding affinities of eight kinds of prenylated isoflavones isolated from Millettia pachycarpa (Leguminosae), and those of two kinds of non-prenylated compounds (genistein and daidzein). By comparing these compounds, the pharmacophores for estrogenic/anti-estrogenic activities were elucidated. None of the tested compounds (except genistein) were estrogenic on ligand-dependent yeast-two hybrid assay. On the other hand, 5 isoflavones showed distinct anti-estrogenic activity. Unexpectedly, the most potent antagonists, Isoerysenegalensein E and 6,8-diprenylorobol, showed anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical ER antagonist.
CONCLUSIONS:
This suggests that genistein became an antagonist after prenylation and hydroxylation. The pharmacophores providing genistein with strong anti-estrogenic activity were as follows: prenyl groups of the 6- and 8-positions on the A-ring, hydroxyl group of the 6-prenyl moiety or the B-ring (catechol form), non-cyclization of the prenyl group with the A-ring, and non-hydroxylation of the 8-prenyl group on the A-ring. The ER-binding affinities of the isoflavonoids were not sufficiently high to explain their potent antagonistic activities, thus suggesting 17β-estradiol-non-competitive mechanisms.
Isoerysenegalensein E Description
Source: The herbs of Erythrina indica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Oleracein E

Catalog No: CFN95441
CAS No: 1021950-79-7
Price: $318/5mg
Benzylpropyl acetate

Catalog No: CFN95495
CAS No: 7492-40-2
Price: $318/5mg
Suchilactone

Catalog No: CFN95010
CAS No: 50816-74-5
Price: $338/5mg
Bruceantinol B

Catalog No: CFN95216
CAS No: 1822332-33-1
Price: $318/5mg
3beta-(alpha-L-Arabinopyranosyloxy...

Catalog No: CFN95459
CAS No: 435269-07-1
Price: $318/20mg
Cichoriin

Catalog No: CFN95196
CAS No: 531-58-8
Price: $100/20mg
Apigenin 7-O-(6''-O-malonylglucosi...

Catalog No: CFN95163
CAS No: 86546-87-4
Price: $318/5mg
Momordicine V

Catalog No: CFN95164
CAS No: 1012315-36-4
Price: $463/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3669 mL 11.8343 mL 23.6686 mL 47.3373 mL 59.1716 mL
5 mM 0.4734 mL 2.3669 mL 4.7337 mL 9.4675 mL 11.8343 mL
10 mM 0.2367 mL 1.1834 mL 2.3669 mL 4.7337 mL 5.9172 mL
50 mM 0.0473 mL 0.2367 mL 0.4734 mL 0.9467 mL 1.1834 mL
100 mM 0.0237 mL 0.1183 mL 0.2367 mL 0.4734 mL 0.5917 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nat Prod Commun. 2014 Jun;9(6):817-20.
Three new isoflavonoids from Erythrina caffra.[Pubmed: 25115087]

METHODS AND RESULTS:
Three new isoflavonoids, 5,7-dihydroxy-2',4'-dimethoxy-5'-(3-methylbut-2-enyl) isoflavanone (erycaffra A) (1), 5,7-dihydroxy-2',4'-dimethoxy-5'-(2-hydroxy-3-methylbut-3-enyl)isoflavanone (erycaffra B) (2), and 5,7-dihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)isoflavone (erycaffra C) (3), were isolated from the stem bark of E. caffra Thunb., along with eight known compounds, namely, alpinumisoflavone (4), Isoerysenegalensein E (5), beta-amyrin (6), oleanolic acid (7), octacosyl-E-ferulate (8), triacontyl-4-hydroxycinnamate (9), n-tetracosyl p-coumarate (10) and octacosan-1-ol (11). The structures were determined on the basis of spectroscopic (1D, 2D-NMR) and MS data and by comparison with literature values.
Secologanic acid

Catalog No: CFN95028
CAS No: 60077-46-5
Price: $318/20mg
Costunolide

Catalog No: CFN98928
CAS No: 553-21-9
Price: $40/20mg
Napellonine

Catalog No: CFN90393
CAS No: 509-24-0
Price: $218/20mg
Croceic acid

Catalog No: CFN90226
CAS No: 27876-94-4
Price: $60/20mg
Quercetin-3-o-rutinose

Catalog No: CFN92447
CAS No: 949926-49-2
Price: $ / mg
Syringin

Catalog No: CFN99282
CAS No: 118-34-3
Price: $80/20mg
Vaccarin

Catalog No: CFN90131
CAS No: 53452-16-7
Price: $30/20mg
Secoxyloganin

Catalog No: CFN98996
CAS No: 58822-47-2
Price: $118/20mg
8-Hydroxypinoresinol

Catalog No: CFN92432
CAS No: 81426-17-7
Price: $ / mg
Ganoderic acid K

Catalog No: CFN92057
CAS No: 104700-95-0
Price: $318/5mg
Tags: buy Isoerysenegalensein E | Isoerysenegalensein E supplier | purchase Isoerysenegalensein E | Isoerysenegalensein E cost | Isoerysenegalensein E manufacturer | order Isoerysenegalensein E | Isoerysenegalensein E distributor