Isorhamnetin 3-glucuronide | CAS:36687-76-0

Isorhamnetin 3-glucuronide

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Description:

Isorhamnetin 3 -O -glucuronide exerts anti-inflammatory activity by increasing heme oxygenase-1 (HO-1) expression and by suppressing Jun N-terminal kinase (JNK) and p38 signaling pathways in LPS-challenged RAW264.7 macrophage cells. Isorhamnetin 3-glucuronide can inhibit vascular cell adhesion molecule-1 (VCAM-1) cell surface expression at 2 micromol/L, indicates that it can inhibit the expression of key molecules involved in monocyte recruitment during the early stages of atherosclerosis at physiological concentrations. It (1 mg/kg i.v.) can progressively reduce mean blood pressure (MBP), measured in conscious spontaneously hypertensive rats (SHR).

Targets:

HO-1 | JNK | p38MAPK

In vivo:

Plos One, 2012, 7(3):e32673.

Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation.[Pubmed: 22427863 ]

METHODS AND RESULTS:
We have analyzed the effects on blood pressure and vascular function in vitro of the conjugated metabolites of quercetin (quercetin-3-glucuronide, Q3GA; Isorhamnetin 3-glucuronide, I3GA; and quercetin-3'-sulfate, Q3'S) in spontaneously hypertensive rats (SHR). Q3GA and I3GA (1 mg/kg i.v.), but not Q3'S, progressively reduced mean blood pressure (MBP), measured in conscious SHR. The hypotensive effect of Q3GA was abolished in SHR treated with the specific inhibitor of β-glucuronidase, saccharic acid 1,4-lactone (SAL, 10 mg/ml). In mesenteric arteries, unlike quercetin, Q3GA had no inhibitory effect in the contractile response to phenylephrine after 30 min of incubation. However, after 1 hour of incubation Q3GA strongly reduced this contractile response and this effect was prevented by SAL. Oral administration of quercetin (10 mg/Kg) induced a progressive decrease in MBP, which was also suppressed by SAL. Conjugated metabolites are involved in the in vivo antihypertensive effect of quercetin, acting as molecules for the plasmatic transport of quercetin to the target tissues.
CONCLUSIONS:
Quercetin released from its glucuronidated metabolites could be responsible for its vasorelaxant and hypotensive effect.

Isorhamnetin 3-glucuronide Description

Source:	The herbs of Potentilla discolor Bge.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Isorhamnetin 3-glucuronide
Price:
CAS No.:	36687-76-0
Catalog No.:	CFN90568
Molecular Formula:	C₂₂H₂₀O₁₃
Molecular Weight:	492.39 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Potentilla discolor Bge.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antihypertensive Compound Library Flavonoids Compound Library p38MAPK Inhibitor Library JNK Inhibitor Library HO-1 Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0309 mL	10.1546 mL	20.3091 mL	40.6182 mL	50.7728 mL
5 mM	0.4062 mL	2.0309 mL	4.0618 mL	8.1236 mL	10.1546 mL
10 mM	0.2031 mL	1.0155 mL	2.0309 mL	4.0618 mL	5.0773 mL
50 mM	0.0406 mL	0.2031 mL	0.4062 mL	0.8124 mL	1.0155 mL
100 mM	0.0203 mL	0.1015 mL	0.2031 mL	0.4062 mL	0.5077 mL

CFN95488	Isorhamnetin 3,5-O-diglucoside	2035413-03-5	640.6	C₂₈H₃₂O₁₇
CFN95769	Isorhamnetin 3-O-apiosyl (1→2)[rhamnosyl (1→6)]glucoside	165605-18-5	756.7	C₃₃H₄₀O₂₀
CFN95787	Morindaparvin W	2596365-67-0	772.7	C₃₃H₄₀O₂₁
CFN98146	Typhaneoside	104472-68-6	770.69	C₃₄H₄₂O₂₀
CFN96156	Ombuin 3-glucoside	158642-42-3	492.4	C₂₃H₂₄O₁₂
CFN95118	Polygalin C	934768-05-5	624.6	C₂₈H₃₂O₁₆
CFN95175	Polygalin J	N/A	874.8	C₄₁H₄₆O₂₁
CFN92808	Ombuoside	20188-85-6	638.6	C₂₉H₃₄O₁₆
CFN91527	Tamarixetin 7-O-neohesperidoside	28283-76-3	624.6	C₂₈H₃₂O₁₆
CFN91115	Isorhamnetin 7-O-glucoside	6743-96-0	478.4	C₂₂H₂₂O₁₂