Kulactone | CAS:22611-36-5 | Manufacturer ChemFaces

Kulactone

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Description:

Kulactone has cytotoxic effects, with IC₅₀ values of 5.6-21.2 ug/mL, it inhibited (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line.

Targets:

Antifection

In vitro:

Nat Prod Res. 2016 Sep;30(17):1984-7.

Antimicrobial compounds from root, stem bark and seeds of Melia volkensii.[Pubmed: 26517430]

Three compounds, toosendanin (1), Kulactone (2) and scopoletin (3), were isolated from either the root bark and/or the stem bark of Melia volkensii. Their structures were determined on the basis of spectroscopic data generated and by comparison with data from the literature.
METHODS AND RESULTS:
1 and 2, isolated for the first time from M. volkensii, exhibited significant (p < 0.05) activity against Escherichia coli with minimum inhibitory concentration of 12.5 μg/mL, close to that of neomycin (6.25 μg/mL). The compounds also exhibited high activity against Aspergillus niger (MIC 6.25 μg/mL compared to 2.5 μg/mL for clotrimazole). Dichloromethane and methanol seed, hexane stem bark and methanol root bark extracts exhibited activities towards Escherichia coli, Staphylococcus aureus, Aspergillus niger and Plasmodium falciparum, respectively.
CONCLUSIONS:
Antimicrobial activity of the plant towards A. niger, P. falciparum and S. aureus is reported for the first time in the current work.

Kulactone Description

Source:	The seeds of Melia toosendan
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Nat Prod. 2002 Dec;65(12):1886-91.

Antineoplastic agents. 489. Isolation and structures of meliastatins 1-5 and related euphane triterpenes from the tree Melia dubia.[Pubmed: 12502333 ]

METHODS AND RESULTS:
The bark of the giant neem tree Melia dubia was found to contain 11 euphane-type triterpenes. Five new compounds, meliastatins 1-5 (1-5), proved to inhibit growth of the P388 lymphocytic leukemia cell line (ED(50) 1.7-5.6 microg/mL). Four of the others, the previously known methyl kulonate (8), kulinone (9), 16-hydroxybutyrospermol (10), and Kulactone (11), were also found to inhibit (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line. In addition, two new euphane triterpenes were isolated and named dubione A (6) and dubione B (7).
CONCLUSIONS:
Structures for each of the 11 euphane triterpenes were established by spectral techniques that included HRMS and 2D NMR.

Product Name	Kulactone
Price:
CAS No.:	22611-36-5
Catalog No.:	CFN92976
Molecular Formula:	C₃₀H₄₄O₃
Molecular Weight:	452.67 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Oil
Source:	The seeds of Melia toosendan
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2091 mL	11.0456 mL	22.0911 mL	44.1823 mL	55.2279 mL
5 mM	0.4418 mL	2.2091 mL	4.4182 mL	8.8365 mL	11.0456 mL
10 mM	0.2209 mL	1.1046 mL	2.2091 mL	4.4182 mL	5.5228 mL
50 mM	0.0442 mL	0.2209 mL	0.4418 mL	0.8836 mL	1.1046 mL
100 mM	0.0221 mL	0.1105 mL	0.2209 mL	0.4418 mL	0.5523 mL

CFN97842	3-Epimeliasenin B	1222475-77-5	468.68	C₃₀H₄₄O₄
CFN99339	Meliasenin B	1221262-77-6	468.7	C₃₀H₄₄O₄
CFN97113	Sendanolactone	64929-59-5	466.7	C₃₀H₄₂O₄
CFN96965	Deoxyflindissone	107176-31-8	438.69	C₃₀H₄₆O₂
CFN96966	Bisabola-2,10-diene-1,9-dione	107439-25-8	234.33	C₁₅H₂₂O₂
CFN96565	Amooracetal	1351617-73-6	516.75	C₃₂H₅₂O₅
CFN97951	21,23:24,25-Diepoxy-21,23-dimethoxytirucall-7-en-3-one	1351617-74-7	514.8	C₃₂H₅₀O₅
CFN99807	Odoratone	16962-90-6	472.7	C₃₀H₄₈O₄
CFN97185	Bourjotinolone A	6985-35-9	472.7	C₃₀H₄₈O₄
CFN97222	Hispidone	73891-72-2	472.7	C₃₀H₄₈O₄