Kuwanon H | CAS:76472-87-2 | Manufacturer ChemFaces

Kuwanon H

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Size /Price /Stock	10 mM * 1 mL in DMSO / $170.3 / In-stock
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Description:

Kuwanon H, and possibly kuwanon G also, are specific antagonists for the gastrin-releasing peptide (GRP) -preferring receptor and can be useful for studying the physiological and pathological role of GRP.

Targets:

GRP

In vitro:

Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9.

Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry.[Pubmed: 7646517 ]

METHODS AND RESULTS:
Kuwanon G and H, isolated from the methanol extract of Morus bombycis, inhibited specific binding of [125I]gastrin-releasing peptide (GRP) to GRP-preferring receptors in murine Swiss 3T3 fibroblasts with Ki values of 470 and 290 nM, respectively. Kuwanon H was one order of magnitude less potent for inhibiting [125I]bombesin binding to neuromedin B (NMB)-preferring receptors in rat esophagus membranes. This compound antagonized bombesin-induced increases in the cytosolic free calcium concentration and GRP-induced DNA synthesis in Swiss 3T3 cells.
CONCLUSIONS:
Thus, Kuwanon H, and possibly kuwanon G also, are specific antagonists for the GRP-preferring receptor and can be useful for studying the physiological and pathological role of GRP.

Kuwanon H Description

Source:	The root barks of Morus alba L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Kuwanon H
Price:	$238 / 10mg
CAS No.:	76472-87-2
Catalog No.:	CFN90835
Molecular Formula:	C₄₅H₄₄O₁₁
Molecular Weight:	760.8 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The root barks of Morus alba L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antagonists Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3144 mL	6.572 mL	13.1441 mL	26.2881 mL	32.8601 mL
5 mM	0.2629 mL	1.3144 mL	2.6288 mL	5.2576 mL	6.572 mL
10 mM	0.1314 mL	0.6572 mL	1.3144 mL	2.6288 mL	3.286 mL
50 mM	0.0263 mL	0.1314 mL	0.2629 mL	0.5258 mL	0.6572 mL
100 mM	0.0131 mL	0.0657 mL	0.1314 mL	0.2629 mL	0.3286 mL

CFN97239	Artocarpin	7608-44-8	436.5	C₂₆H₂₈O₆
CFN97892	3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone	1334309-44-2	490.6	C₃₀H₃₄O₆
CFN90834	Kuwanon A	62949-77-3	420.5	C₂₅H₂₄O₆
CFN92416	Sanggenone K	86450-77-3	488.6	C₃₀H₃₂O₆
CFN93278	Kuwanon G	75629-19-5	692.71	C₄₀H₃₆O₁₁
CFN90835	Kuwanon H	76472-87-2	760.8	C₄₅H₄₄O₁₁
CFN92322	5,7,2',4'-Tetrahydroxy-3-geranylflavone	376361-87-4	422.5	C₂₅H₂₆O₆
CFN97085	Mulberrin	62949-79-5	422.5	C₂₅H₂₆O₆
CFN97083	Morusin	62596-29-6	420.5	C₂₅H₂₄O₆
CFN97086	Morusinol	62949-93-3	438.5	C₂₅H₂₆O₇