L-4-Hydroxyisoleucine | CAS:6001-78-8 | Manufacturer ChemFaces

L-4-Hydroxyisoleucine

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $62.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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L-4-Hydroxyisoleucine Description

Source:	The seeds of Trigonella foenum-graecum L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Microbiologyopen. 2013 Jun;2(3):471-81.

A novel l-isoleucine-4'-dioxygenase and l-isoleucine dihydroxylation cascade in Pantoea ananatis.[Pubmed: 23554367 ]

A unique operon structure has been identified in the genomes of several plant- and insect-associated bacteria. The distinguishing feature of this operon is the presence of tandem hilA and hilB genes encoding dioxygenases belonging to the PF13640 and PF10014 (BsmA) Pfam families, respectively.
METHODS AND RESULTS:
The genes encoding HilA and HilB from Pantoea ananatis AJ13355 were cloned and expressed in Escherichia coli. The culturing of E. coli cells expressing hilA (E. coli-HilA) or both hilA and hilB (E. coli-HilAB) in the presence of l-isoleucine resulted in the conversion of l-isoleucine into two novel biogenic compounds: l-4'-isoleucine and l-4,4'-dihydroxyisoleucine, respectively. In parallel, two novel enzymatic activities were detected in the crude cell lysates of the E. coli-HilA and E. coli-HilAB strains: l-isoleucine, 2-oxoglutarate: oxygen oxidoreductase (4'-hydroxylating) (HilA) and l-4'-hydroxyisoleucine, 2-oxoglutarate: oxygen oxidoreductase (4-hydroxylating) (HilB), respectively. Two hypotheses regarding the physiological significance of C-4(4')-hydroxylation of l-isoleucine in bacteria are also discussed.
CONCLUSIONS:
According to first hypothesis, the l-isoleucine dihydroxylation cascade is involved in synthesis of dipeptide antibiotic in P. ananatis. Another unifying hypothesis is that the C-4(4')-hydroxylation of l-isoleucine in bacteria could result in the synthesis of signal molecules belonging to two classes: 2(5H)-furanones and analogs of N-acyl homoserine lactone.

Product Name	L-4-Hydroxyisoleucine
Price:	$288 / 20mg
CAS No.:	6001-78-8
Catalog No.:	CFN90214
Molecular Formula:	C₆H₁₃NO₃
Molecular Weight:	147.17 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The seeds of Trigonella foenum-graecum L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.7949 mL	33.9743 mL	67.9486 mL	135.8973 mL	169.8716 mL
5 mM	1.359 mL	6.7949 mL	13.5897 mL	27.1795 mL	33.9743 mL
10 mM	0.6795 mL	3.3974 mL	6.7949 mL	13.5897 mL	16.9872 mL
50 mM	0.1359 mL	0.6795 mL	1.359 mL	2.7179 mL	3.3974 mL
100 mM	0.0679 mL	0.3397 mL	0.6795 mL	1.359 mL	1.6987 mL

CFN90028	4-Aminobutanoic acid	56-12-2	103.12	C₄H₉NO₂
CFN90013	Pregabalin	148553-50-8	159.23	C₈H₁₇NO₂
CFN90214	L-4-Hydroxyisoleucine	6001-78-8	147.17	C₆H₁₃NO₃
CFN99739	L-Carnitine inner salt	541-15-1	161.20	C₇H₁₅NO₃
CFN90064	Tetraethoxypropane	122-31-6	220.31	C₁₁H₂₄O₄
CFN98511	Tricine	5704-04-1	179.17	C₆H₁₃NO₅
CFN90413	Dencichin	7554-90-7	176.13	C₅H₈N₂O₅
CFN90056	NG,NG-Dimethylarginine dihydrochloride	220805-22-1	275.18	C₈H₂₀Cl₂N₄O₂