Science | Nature | Cell | View More
Natural Products
Licraside
Licraside
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Licraside
Price: $368 / 10mg
CAS No.: 29913-71-1
Catalog No.: CFN91792
Molecular Formula: C26H30O13
Molecular Weight: 550.51 g/mol
Purity: >=98%
Type of Compound: Chalcones
Physical Desc.: Powder
Source: The roots of Glycyrrhiza uralensis
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $229.0 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Massachusetts General Hospital (USA)
  • University of Cincinnati (USA)
  • Seoul National University (Korea)
  • University of Wisconsin-Madison (USA)
  • University of Maryland (USA)
  • Institute of Tropical Disease U... (Indonesia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Universidade do Porto (Portugal)
  • St. Jude Children Research Hosp... (USA)
  • Universidad de Buenos Aires (Argentina)
  • Ain Shams University (Egypt)
  • More...
Package
Featured Products
Panaxydol

Catalog No: CFN92797
CAS No: 72800-72-7
Price: $448/20mg
Nobiletin

Catalog No: CFN98726
CAS No: 478-01-3
Price: $30/20mg
Oxypeucedanin

Catalog No: CFN90350
CAS No: 737-52-0
Price: $80/20mg
Dauricine

Catalog No: CFN98129
CAS No: 524-17-4
Price: $98/20mg
Delphinidin-3-O-rutinoside chloride

Catalog No: CFN92136
CAS No: 15674-58-5
Price: $383/5mg
(2-Acetoxyethyl)trimethylammonium

Catalog No: CFN00011
CAS No: 51-84-3
Price: $ /
Isochlorogenic acid C(4,5)

Catalog No: CFN90354
CAS No: 57378-72-0
Price: $60/20mg
L-Glutamic acid

Catalog No: CFN93108
CAS No: 56-86-0
Price: $30/20mg
Lupenone

Catalog No: CFN99681
CAS No: 1617-70-5
Price: $178/20mg
Capsanthin

Catalog No: CFN70366
CAS No: 465-42-9
Price: $ / mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Licraside(licuraside) has potency and ability to inhibit mushroom tyrosinase monophenolase activity with an IC(50) value of 0.072 mM. Licraside(Licurazid) has anticancer properties.
In vitro:
J Agric Food Chem. 2005 Sep 21;53(19):7408-7414.
Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase[Pubmed: 16159166]
Five different flavonoids were isolated from licorice after multistep chromatographic fractionation. The aim was to identify and characterize active components in licorice responsible for antibrowning activities and to seek new tyrosinase inhibitors for applications as antibrowning and depigmenting agents in the food and cosmetic industries. The isolated flavonoids were identified as liquiritin, licuraside, isoliquiritin, liquiritigenin (from Glycyrrhiza uralensis Fisch.), and licochalcone A (from Glycyrrhiza inflate Bat.) by UV, MS, (1)H NMR, and (13)C NMR analyses. The inhibitory potencies and capacities of these flavonoids toward monophenolase activity of mushroom tyrosinase were investigated. The IC(50) values of licuraside, isoliquiritin, and licochalcone A for monophenolase activity were 0.072, 0.038, and 0.0258 mM, respectively. A study of the mechanisms of monophenolase inhibition by these flavonoids indicated that they are all competitive inhibitors. Different from the above flavonoids, no inhibitory activity was observed for liquiritin, whereas liquiritigenin activated the monophenolase activity as a cofactor. The inhibitory effect of licuraside, isoliquiritin, and licochalcone A on diphenolase activity with l-DOPA as the substrate was much lower than those with l-tyrosine. Results suggest that licuraside, isoliquiritin, and licochalcone A have the high potential to be further developed into effective antibrowning and depigmenting agents.
Planta Med . 1989 Feb;55(1):22-26.
The existence of aldose reductase inhibitors in some kampo medicines (Oriental herb prescriptions)[Pubmed: 2497475]
Traditionally in Japan, some kampo medicines which contain Glycyrrhizae radix (GR) and Paeoniae radix (PR) have long been used for the treatment of diabetic neuropathy. Since we have previously shown that GR und PR have potent aldose reductase inhibitory activities, we further investigated the constituents of these two. The boiled water extract of GR was applied to Sephadex LH-20 column chromatography and 6 fractions (Frs. A, B, Cs, Cp, D, and E) were obtained. Frs. Cp and D were retreated in the same manner and 7 pure compounds (GUs 1-7) were obtained. The boiled water extract of PR was fractionated with ethyl acetate followed by n-butanol and 3 fractions (Frs. 1-3) were collected. Fr. 1 was retreated in the same manner and 2 pure compounds (PRs 1 and 2) were obtained. Among the GU compounds, GU-2 was the most potent inhibitor of rat lens aldose reductase (RLAR) by inhibiting 86% at the concentration of 1.0 microgram/ml. The IC50 of GU-2 was 7.2 x 10(-7) M. Furthermore, GU-2 markedly inhibited sorbitol accumulation in human red blood cells, having an IC50 of 2.9 x 10(-5) M. GU-5 and PR-1 also inhibited RLAR (IC50: 5.6 x 10(-7) M and 6.3 x 10(-7) M, respectively). The structures of GU-2, GU-5, and PR-1 were identified as isoliquiritin, licuraside, and 1, 2, 3, 6-tetra-O-galloyl-beta-D-glucose, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Anticancer Res. 2013 Aug;33(8):3061-3068.
Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure[Pubmed: 23898061]
Background: The mechanism of cytotoxicity induction by flavonoids has been studied by many investigators, but their tumor specificity is not clear. To address this point, 10 licorice flavonoids were subjected to quantitative structure-activity relationship (QASR) analysis with cytotoxicity assay with four human oral carcinoma and three normal cell lines. Materials and methods: Cytotoxicity was determined by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide method. Physico-chemical, structural, and quantum-chemical parameters were calculated based on the conformations optimized by the LowModeMD method. Results: Licurazid and isoliquiritigenin had the highest cytotoxicity against tumor cells, and liquiritin, isoliquiritin and licurazid had the highest tumor specificity, suggesting an antitumor potential for licurazid. Chalcones had slightly higher cytotoxicity and tumor specificity than flavanones. The number of sugar units in the molecule was somewhat negatively-correlated with cytotoxicity, but not with tumor specificity. Parameters that reflect the three-dimensional structure, molecular volume and number of phenolic OH groups were significantly correlated with cytotoxicity, but not with tumor specificity. On the other hand, solvation energy was significantly correlated with tumor specificity, but not with cytotoxicity. Conclusion: These physicochemical descriptors may be useful to estimate cytotoxicity or tumor specificity of structurally-related compounds to these licorice flavonoids.
Licraside Description
Source: The roots of Glycyrrhiza uralensis
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Apigenin 6,8-di-C-alpha-L-arabinop...

Catalog No: CFN95360
CAS No: 73140-47-3
Price: $318/10mg
Gossypetin 3-sophoroside-8-glucosi...

Catalog No: CFN95528
CAS No: 77306-93-5
Price: $318/5mg
Ganoderiol D

Catalog No: CFN95568
CAS No: 114567-45-2
Price: $413/5mg
(1S,2S)-threo-Honokitriol

Catalog No: CFN95076
CAS No: 1099687-80-5
Price: $413/5mg
Macrophylloside D

Catalog No: CFN95113
CAS No: 179457-69-3
Price: $318/10mg
1-Phenylethyl beta-D-glucoside

Catalog No: CFN95574
CAS No: 93199-03-2
Price: $318/5mg
Phloretin 3',5'-Di-C-glucoside

Catalog No: CFN95306
CAS No: 357401-40-2
Price: $318/10mg
3'-Hydroxy-5,7,4'-trimethoxyflavon...

Catalog No: CFN95396
CAS No: 33554-52-8
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8165 mL 9.0825 mL 18.165 mL 36.3299 mL 45.4124 mL
5 mM 0.3633 mL 1.8165 mL 3.633 mL 7.266 mL 9.0825 mL
10 mM 0.1816 mL 0.9082 mL 1.8165 mL 3.633 mL 4.5412 mL
50 mM 0.0363 mL 0.1816 mL 0.3633 mL 0.7266 mL 0.9082 mL
100 mM 0.0182 mL 0.0908 mL 0.1816 mL 0.3633 mL 0.4541 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Agric Food Chem. 2005 Sep 21;53(19):7408-7414.
Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase[Pubmed: 16159166]
Five different flavonoids were isolated from licorice after multistep chromatographic fractionation. The aim was to identify and characterize active components in licorice responsible for antibrowning activities and to seek new tyrosinase inhibitors for applications as antibrowning and depigmenting agents in the food and cosmetic industries. The isolated flavonoids were identified as liquiritin, licuraside, isoliquiritin, liquiritigenin (from Glycyrrhiza uralensis Fisch.), and licochalcone A (from Glycyrrhiza inflate Bat.) by UV, MS, (1)H NMR, and (13)C NMR analyses. The inhibitory potencies and capacities of these flavonoids toward monophenolase activity of mushroom tyrosinase were investigated. The IC(50) values of licuraside, isoliquiritin, and licochalcone A for monophenolase activity were 0.072, 0.038, and 0.0258 mM, respectively. A study of the mechanisms of monophenolase inhibition by these flavonoids indicated that they are all competitive inhibitors. Different from the above flavonoids, no inhibitory activity was observed for liquiritin, whereas liquiritigenin activated the monophenolase activity as a cofactor. The inhibitory effect of licuraside, isoliquiritin, and licochalcone A on diphenolase activity with l-DOPA as the substrate was much lower than those with l-tyrosine. Results suggest that licuraside, isoliquiritin, and licochalcone A have the high potential to be further developed into effective antibrowning and depigmenting agents.
Panaxydol

Catalog No: CFN92797
CAS No: 72800-72-7
Price: $448/20mg
Nobiletin

Catalog No: CFN98726
CAS No: 478-01-3
Price: $30/20mg
Oxypeucedanin

Catalog No: CFN90350
CAS No: 737-52-0
Price: $80/20mg
Dauricine

Catalog No: CFN98129
CAS No: 524-17-4
Price: $98/20mg
Delphinidin-3-O-rutinoside chloride

Catalog No: CFN92136
CAS No: 15674-58-5
Price: $383/5mg
(2-Acetoxyethyl)trimethylammonium

Catalog No: CFN00011
CAS No: 51-84-3
Price: $ /
Isochlorogenic acid C(4,5)

Catalog No: CFN90354
CAS No: 57378-72-0
Price: $60/20mg
L-Glutamic acid

Catalog No: CFN93108
CAS No: 56-86-0
Price: $30/20mg
Lupenone

Catalog No: CFN99681
CAS No: 1617-70-5
Price: $178/20mg
Capsanthin

Catalog No: CFN70366
CAS No: 465-42-9
Price: $ / mg
Tags: buy Licraside | Licraside supplier | purchase Licraside | Licraside cost | Licraside manufacturer | order Licraside | Licraside distributor