| Structure Identification: |
| Planta Medica,2014,80(10):783-783. | | Identification of phenolic compounds from the flower buds of Tussilago farfara and their antioxidative effects[Reference: WebLink] | The dried flower buds of Tussilago farfara L. (Compositae) have been traditionally used to treat cough and asthma. There have been reports on various biological activities of its constituents such as anti-inflammatory, α-glucosidase inhibitory, and diacylglycerol acyltransferase (DGAT) inhibitory effect.
METHODS AND RESULTS:
As a part of our ongoing search for bioactive compounds from traditional herbal medicines, the flower buds of T. farfara were investigated and one new compound, 1-[(4S)-3,4-dihydro-4-hydroxy-2,2-dimethyl-2 H-1-benzopyran-6-yl]-ethanone (1), together with eight known compounds, 3,4-O-dicaffeoyl isoquinic acid (2), trans-cinnamic acid (3), 4-hydroxyacetophenone (4), 4,5-dicaffeoylquinic acid methyl ester (5), 3,5-dicaffeoylquinic acid methyl ester (6), 4-hydroxybenzoic acid (7), isoquercetin (8), Ligucyperonol (9) were isolated. Among them, compounds 2 – 4 have never been isolated from this plant previously. Their structures were identified by spectroscopic analysis including 1D and 2D NMR experiments.
CONCLUSIONS:
Moreover, all of the isolates were evaluated for their antioxidative effects and exhibited significant activities on protecting muscle cells from mild to moderate oxidative stress. |
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